Principal Scientist, Clinical Pharmacology & Pharmacometrics

Role: Principal Scientist, Clinical Pharmacology and Pharmacometrics, leading strategy and modeling efforts for oncology drug development. Responsibilities: formulate and execute pharmacology strategies for preclinical and clinical assets; apply PK/PD, PBPK, and modeling & simulation approaches to inform dose selection and go/no-go decisions; collaborate with CROs and internal teams on study design, execution, data analysis, and regulatory documentation; contribute to program development and regulatory interactions. Requirements: Ph.D. or PharmD in pharmacology, clinical pharmacology, or related field; 2-5 years in biotech/pharma with experience across modalities (small molecule, biologics, ADCs); proficiency in modeling software (WINNONLIN, NONMEM, MONOLIX, PBPK tools); strong knowledge of oncology drug development and regulatory guidance. High-Value: oncology, ADCs, RLTs, pharmacometric modeling, regulatory interaction, global clinical pharmacology strategy, regulated bioanalytical environment. WorkSetup: not specified; experience managing multiple workstreams and collaborating across functions essential.