Principal Scientist, Cell Line Genome Engineering
Bristol Myers Squibb
August 14, 2026
Remote friendly (Princeton, NJ)
United States
Clinical Research and Development
Responsibilities:
- Design, engineer, and validate physiologically and/or disease-relevant cellular systems to enable initiation and progression of drug discovery programs.
- Develop advanced engineered cellular models to support drug discovery within Lead Discovery and Optimization.
- Guide project teams in selecting appropriate cellular models at project outset to ensure biological alignment and maximize translational impact.
- Collaborate with internal teams and external academic/industry partners; integrate insights into innovative, research-driven solutions.
Qualifications:
- Master’s degree in molecular biology, cell biology, bioengineering (or related) and 6+ years academic/industry experience OR PhD and 4+ years academic/industry experience.
Required/Preferred Skills (from posting):
- Deep genome biology knowledge (gene regulation and impact on cellular function) applied to engineered cellular systems.
- Hands-on CRISPR genome engineering (e.g., Cas9/Cas12a/dCas9; base/prime editing) and gene delivery methods (lentiviral, AAV, electroporation, transposon) to build/scale/optimize cellular models.
- Expertise engineering diverse cellular systems (established cell lines, primary cells, physiologically relevant models) and model selection for discovery questions.
- High-content imaging and cell painting experience.
- Genomic sequence analysis/bioinformatics including short/long-read sequencing for experimental design, clonal characterization, and validation.
- Experience integrating AI-guided/AI-enabled cell line engineering (computational models to design/interpret perturbations and phenotypes).
- Strong analytical/data interpretation skills; ability to influence scientific/strategic decisions.
- Lead/influence cross-functional teams in a matrixed environment; excellent communication.
Benefits (explicitly listed): Health coverage; wellbeing support programs; 401(k), disability/life/insurance, legal support; paid time off (including flexible time off/annual vacation per eligibility) and potential additional time off (e.g., sick time, volunteer days, leaves, Global Shutdown).
Application instructions:
- Apply for the role “R1605341 Principal Scientist, Cell Line Genome Engineering.”
- Design, engineer, and validate physiologically and/or disease-relevant cellular systems to enable initiation and progression of drug discovery programs.
- Develop advanced engineered cellular models to support drug discovery within Lead Discovery and Optimization.
- Guide project teams in selecting appropriate cellular models at project outset to ensure biological alignment and maximize translational impact.
- Collaborate with internal teams and external academic/industry partners; integrate insights into innovative, research-driven solutions.
Qualifications:
- Master’s degree in molecular biology, cell biology, bioengineering (or related) and 6+ years academic/industry experience OR PhD and 4+ years academic/industry experience.
Required/Preferred Skills (from posting):
- Deep genome biology knowledge (gene regulation and impact on cellular function) applied to engineered cellular systems.
- Hands-on CRISPR genome engineering (e.g., Cas9/Cas12a/dCas9; base/prime editing) and gene delivery methods (lentiviral, AAV, electroporation, transposon) to build/scale/optimize cellular models.
- Expertise engineering diverse cellular systems (established cell lines, primary cells, physiologically relevant models) and model selection for discovery questions.
- High-content imaging and cell painting experience.
- Genomic sequence analysis/bioinformatics including short/long-read sequencing for experimental design, clonal characterization, and validation.
- Experience integrating AI-guided/AI-enabled cell line engineering (computational models to design/interpret perturbations and phenotypes).
- Strong analytical/data interpretation skills; ability to influence scientific/strategic decisions.
- Lead/influence cross-functional teams in a matrixed environment; excellent communication.
Benefits (explicitly listed): Health coverage; wellbeing support programs; 401(k), disability/life/insurance, legal support; paid time off (including flexible time off/annual vacation per eligibility) and potential additional time off (e.g., sick time, volunteer days, leaves, Global Shutdown).
Application instructions:
- Apply for the role “R1605341 Principal Scientist, Cell Line Genome Engineering.”