Principal Scientist, Cell Line Genome Engineering
Bristol Myers Squibb
August 30, 2026
Remote friendly (Princeton, NJ)
United States
Clinical Research and Development
Responsibilities:
- Design, engineer, and validate physiologically and/or disease-relevant cellular systems to enable initiation and progression of drug discovery programs.
- Develop advanced engineered cellular models supporting Lead Discovery and Optimization.
- Guide project teams in selecting appropriate cellular models at project outset to ensure biological alignment and maximize translational impact.
- Collaborate with internal teams and external academic/industry partners; integrate collaboration insights into research-driven solutions.
Qualifications (Successful Candidate Will Have):
- Deep understanding of genome biology and gene regulation; ability to apply this knowledge to engineered cellular systems for drug discovery.
- Hands-on/strategic expertise in CRISPR-based genome engineering (e.g., Cas9/Cas12a/dCas9, base/prime editing) and gene delivery methods (lentiviral, AAV, electroporation, transposon) to build and optimize cellular models.
- Expertise engineering diverse cellular systems (cell lines, primary cells, physiologically relevant models) and advising model selection.
- Experience with high-content imaging/cell painting for drug discovery.
- Genomic sequence analysis and bioinformatics, including short/long-read sequencing, for clonal characterization and engineered-system validation.
- Experience integrating emerging functional genomics/AI-guided cell line engineering; strong analytical and data interpretation skills.
- Proven cross-functional leadership in matrixed environments; strong communication; commitment to innovation and continuous learning.
Basic Qualifications:
- Master’s in molecular/cell biology, bioengineering or related + 6+ years academic/industry, OR PhD + 4+ years.
Preferred Qualifications (highlights):
- PhD with postdoc/industry preferred; demonstrated genetically engineered system design (KO/KI/insertions/overexpression).
- iPSC/primary cell genome editing experience; NGS and downstream workflows; ddPCR/TaqMan or similar assays.
Compensation Overview:
- Princeton, NJ, US: $135,800–$164,563.
Application instructions:
- Apply even if you don’t perfectly match; “you could be one step away.”
- Design, engineer, and validate physiologically and/or disease-relevant cellular systems to enable initiation and progression of drug discovery programs.
- Develop advanced engineered cellular models supporting Lead Discovery and Optimization.
- Guide project teams in selecting appropriate cellular models at project outset to ensure biological alignment and maximize translational impact.
- Collaborate with internal teams and external academic/industry partners; integrate collaboration insights into research-driven solutions.
Qualifications (Successful Candidate Will Have):
- Deep understanding of genome biology and gene regulation; ability to apply this knowledge to engineered cellular systems for drug discovery.
- Hands-on/strategic expertise in CRISPR-based genome engineering (e.g., Cas9/Cas12a/dCas9, base/prime editing) and gene delivery methods (lentiviral, AAV, electroporation, transposon) to build and optimize cellular models.
- Expertise engineering diverse cellular systems (cell lines, primary cells, physiologically relevant models) and advising model selection.
- Experience with high-content imaging/cell painting for drug discovery.
- Genomic sequence analysis and bioinformatics, including short/long-read sequencing, for clonal characterization and engineered-system validation.
- Experience integrating emerging functional genomics/AI-guided cell line engineering; strong analytical and data interpretation skills.
- Proven cross-functional leadership in matrixed environments; strong communication; commitment to innovation and continuous learning.
Basic Qualifications:
- Master’s in molecular/cell biology, bioengineering or related + 6+ years academic/industry, OR PhD + 4+ years.
Preferred Qualifications (highlights):
- PhD with postdoc/industry preferred; demonstrated genetically engineered system design (KO/KI/insertions/overexpression).
- iPSC/primary cell genome editing experience; NGS and downstream workflows; ddPCR/TaqMan or similar assays.
Compensation Overview:
- Princeton, NJ, US: $135,800–$164,563.
Application instructions:
- Apply even if you don’t perfectly match; “you could be one step away.”