Principal Scientist - Cardiometabolic Disorders

Role: Principal Scientist leading discovery and preclinical development of therapeutics for obesity and cardiometabolic diseases, focusing on translational pharmacology and target validation. Responsibilities: design and execute in vitro and in vivo pharmacology studies, develop strategies for evaluating novel mechanisms, interpret data to inform candidate selection, and lead cross-functional scientific discussions. Qualifications: PhD in Pharmacology, Physiology, Endocrinology, or related fields with 5+ years in biotech/pharma drug discovery; expertise in GPCR biology, receptor pharmacology, and signaling; experience developing and applying GPCR-based assays, biologic therapeutics, and integrating multi-modal data for decision-making. Preferred: proven leadership, mentorship, and experience in peptide, antibody, or multispecific biologics; strong publication record. High-Value: focus on obesity, metabolic diseases, biologics, and GPCR targets in early discovery phases. Collaboration with biology, engineering, pharmacokinetics, toxicology, and clinical teams. Location details and travel expectations are not specified.