Principal Scientist, Biologics Optimization

Role: Principal Scientist, Biologics Optimization within Johnson & Johnson's Innovative Medicine division, leading efforts to accelerate biologic drug discovery through data integration, antibody engineering, and automation. Responsibilities include providing scientific leadership for automation-enabled workflows, collaborating with cross-functional teams (including computational and automation experts), developing frameworks to transform data into actionable insights, and advancing platform capabilities such as yeast display and NGS. The role emphasizes building scalable, reproducible processes that inform molecule optimization, improve discovery efficiency, and support strategic decision-making. Qualifications: Master’s in Molecular Biology, Biochemistry, or related field; PhD preferred; at least 3 years of relevant industry experience in biologics discovery, protein engineering, or automation; proven leadership in biologics optimization; strong knowledge of antibody structure-function relationships; proficiency in scientific computing and AI/ML tools; experience with biophysical/biochemical characterization techniques and cell-based assays. Preferred skills include experience with high-throughput screening, mammalian expression systems, NGS technologies, and establishing new scientific capabilities. The position requires collaboration across discovery, IT, and automation teams and periodic travel to the Cambridge, MA site. It is based in Spring House, PA, with a focus on advancing therapeutic biologics in oncology, immunology, or related areas.