Principal Scientist, Biochemistry & Biophysics

Role: Lead scientist overseeing biochemical and biophysical assay strategies for early discovery of targeted protein degraders at C4 Therapeutics. Responsibilities: design and optimize assays to characterize protein interactions, lead complex operational workstreams, interpret integrated data to inform compound prioritization, and serve as a scientific partner to project teams. Manage CRO collaborations and contribute to platform development. Qualifications: PhD in biochemistry, biophysics, or related field; 8+ years of post-graduate experience in biotech/pharma, with expertise in protein–protein and protein–small molecule interactions, assay design, and data analysis. High-Value: focus on targeted protein degradation, molecular glues, heterobivalent degraders, with experience in biochemical/biophysical methods such as SPR, BLI, TR-FRET, AlphaLISA. Preferred: knowledge of structural biology, computational chemistry, proteomics, and cell pharmacology; experience managing projects and mentorship. Work setup: not specified, but involves cross-functional collaboration in a fast-paced biotech setting.