Principal Scientist/Associate Director, DMPK
Disc Medicine
August 24, 2026
Remote friendly (Watertown, MA)
United States
Clinical Research and Development
Position Overview:
- Support application of pharmacokinetic (PK) and pharmacodynamic (PD) sciences in drug discovery and development portfolios, with a focus on biologics.
- Characterize ADME and PK/PD properties of small molecules and biologics using in vitro, in vivo, and modeling approaches.
- Serve as a DMPK project representative across portfolio stages from early screening/optimization through IND-enabling studies and regulatory submissions.
Responsibilities:
- Serve as DMPK representative on biologics and/or small molecule project teams, providing scientific and strategic leadership.
- Design, conduct, interpret, and report in vitro ADME, in vivo PK, and PK/PD studies.
- Develop and maintain compound selection criteria.
- Partner with modeling/simulation experts, toxicologists, and clinical pharmacologists to support human PKPD prediction, toxicology, and clinical study support.
- Summarize and present scientific results to project teams, leadership, and stakeholders.
- Oversee external CRO partners to ensure high-quality data generation within budget and timelines.
- Provide expert-level guidance to regulatory submissions for biologics and/or small molecules.
Requirements:
- MS in DMPK/biology/chemistry or related field with 8+ years relevant experience, or PhD (or equivalent) with 5+ years relevant industry experience.
- Demonstrated expertise in large-molecule PK/PKPD and general discovery/development.
- Strong ADME/PK/PKPD knowledge for small molecules (plus).
- Highly preferred: ability to apply innovative PK/PKPD approaches to predict human PK, generate hypotheses, design studies, inform clinical plans, and support regulatory filings.
- Cross-disciplinary collaboration; ability to lead/influence.
- Excellent written and verbal communication.
Application Instructions:
- Submit your resume to be considered for current and future opportunities.
- Support application of pharmacokinetic (PK) and pharmacodynamic (PD) sciences in drug discovery and development portfolios, with a focus on biologics.
- Characterize ADME and PK/PD properties of small molecules and biologics using in vitro, in vivo, and modeling approaches.
- Serve as a DMPK project representative across portfolio stages from early screening/optimization through IND-enabling studies and regulatory submissions.
Responsibilities:
- Serve as DMPK representative on biologics and/or small molecule project teams, providing scientific and strategic leadership.
- Design, conduct, interpret, and report in vitro ADME, in vivo PK, and PK/PD studies.
- Develop and maintain compound selection criteria.
- Partner with modeling/simulation experts, toxicologists, and clinical pharmacologists to support human PKPD prediction, toxicology, and clinical study support.
- Summarize and present scientific results to project teams, leadership, and stakeholders.
- Oversee external CRO partners to ensure high-quality data generation within budget and timelines.
- Provide expert-level guidance to regulatory submissions for biologics and/or small molecules.
Requirements:
- MS in DMPK/biology/chemistry or related field with 8+ years relevant experience, or PhD (or equivalent) with 5+ years relevant industry experience.
- Demonstrated expertise in large-molecule PK/PKPD and general discovery/development.
- Strong ADME/PK/PKPD knowledge for small molecules (plus).
- Highly preferred: ability to apply innovative PK/PKPD approaches to predict human PK, generate hypotheses, design studies, inform clinical plans, and support regulatory filings.
- Cross-disciplinary collaboration; ability to lead/influence.
- Excellent written and verbal communication.
Application Instructions:
- Submit your resume to be considered for current and future opportunities.