Principal Scientist, Antibody Discovery Innovation

Role: Principal Scientist leading in vivo antibody discovery within the Discovery Biologics group, focusing on advancing antibody platforms and strategies for therapeutic development. Responsibilities: oversee in vivo antibody discovery strategies, propose and lead technological innovations to enhance hit quality and reduce timelines, and collaborate with cross-functional teams including therapeutic area scientists. Serve on leadership teams to set strategic goals, foster a culture of collaboration and inclusion, and stay abreast of scientific advancements. Requirements: Ph.D. with 8+ years in biophysics, biochemistry, structural biology, or related fields, with extensive experience supporting antibody drug discovery, particularly in adaptive immunity and B-cell biology. Proven track record in leading therapeutic antibody campaigns, driving platform innovations, and managing high-performance teams. Preferred: experience with non-Ig scaffolds, multi-specifics, fusion proteins, ADCs, and AI/ML applications in lead optimization. High-value: antibody discovery, biologics, immunization-based platforms, therapeutic programs, in vivo strategies, team leadership, and external reputation building. Work setup: based in South San Francisco, with approximately 10% travel; inclusive of remote or hybrid options.