Principal Scientist, Antibody Discovery and Engineering

Role: Principal Scientist leading antibody discovery and engineering within Moderna's Therapeutics Research, focusing on oncology and autoimmune programs. Responsibilities: develop and execute integrated discovery strategies, oversee antibody generation and optimization workflows across formats such as IgG, bispecifics, and CAR-T; partner with structural and computational biology teams; analyze complex datasets; mentor scientists; and contribute to innovative therapeutic modalities. Requirements: PhD in immunology, molecular biology, or related field; 5+ years industry experience in antibody discovery/engineering; expertise in immunization, display technologies, antibody characterization, and molecular biology; proven track record leading discovery campaigns independently. Preferred: 7+ years, experience with advanced formats (e.g., T cell engagers, bispecifics), bioinformatics, structural modeling, and prior impactful publications. High-Value: biologics discovery, therapeutic antibody development, immuno-oncology, autoimmune diseases, early to clinical development stages. Collaboration: cross-functional with antigen design, structural biology, project teams, external CROs; leadership in scientific discussions. Work Setup: not explicitly specified, likely hybrid given corporate culture; no travel specified.