Principal Scientist, Animal Genetic Engineering - Antibody Discovery

Role: Principal Scientist in Animal Genetic Engineering – Antibody Discovery, based in Cambridge, MA or Spring House, PA. Focuses on designing and engineering mouse models to improve antibody discovery, especially against challenging targets like membrane proteins and GPCRs. Responsibilities include developing strategies for genetic model enhancement, managing CRO partnerships for genome editing, and validating models within antibody discovery workflows. The role requires expertise in mouse genetics, CRISPR, B cell immunology, and antibody technologies, with a focus on broadening antibody repertoires and overcoming immune tolerance barriers. Collaborates with cross-functional teams across discovery, immunology, and protein sciences, while ensuring compliance with animal welfare standards. Qualifications: Ph.D. in Immunology, Molecular Biology, Genetics, or related fields, with 3+ years’ industry/academic experience; hands-on mouse genetic engineering (e.g., CRISPR, transgenesis); deep knowledge of B cell biology, immune responses, and antibody discovery methods, especially targeting membrane proteins and GPCRs. Leadership entails independently guiding platform development, strategic planning, and mentoring. The position emphasizes innovation in in vivo models, with high-value biopharma focus on therapeutic antibody discovery against difficult targets, leveraging advanced genetic engineering and immunological insights.