Principal Scientist, Analytical Development and QC, Small Molecule

Role: Principal Scientist, Analytical Development and QC, Small Molecule at Immunome, supporting small molecule therapeutic programs across development stages. Responsibilities: develop and validate phase-appropriate analytical methods for linker payload intermediates, oversee method transfer and troubleshooting, manage external testing labs, lead investigations into analytical discrepancies, and author regulatory documentation. Collaborate closely with discovery, process chemistry, QA, and regulatory teams to ensure analytical strategies align with project goals and regulatory standards. Qualifications: Ph.D. (3+ years), M.S. (8+ years), or B.S. (10+ years) in Analytical Chemistry, Pharmaceutical Sciences, or related field; proven expertise in developing, validating, and transferring analytical methods in cGMP environments; experience with Linker Payload characterization is highly preferred. High-Value: Focus on small molecule drugs, linker-payload properties, cGMP compliance, support for regulatory submissions (IND/CTA, NDA), hands-on experience with LC, GC, LC-MSMS, spectroscopy, and impurity analysis. Work setup involves collaboration with CDMOs and internal teams, with travel up to 25%. The role emphasizes technical leadership in analytical sciences within an oncology-focused pipeline.