Principal Scientist, ADC Technologies
Immunome, Inc.
3 days ago
Remote friendly (Bothell, WA)
United States
Clinical Research and Development
Position Overview:
Immunome seeks a cancer biologist to develop and champion novel therapeutic concepts and engineer next-generation ADC therapeutics by leveraging expertise in cancer biology, drug resistance mechanisms, and pharmacology. In partnership with cross-functional teams, lead the discovery, optimization, and nomination of new drug candidates for clinical development.
Responsibilities:
- Apply oncology and ADC pharmacology to formulate new therapeutic concepts.
- Lead preclinical discovery for novel ADC technologies: linker/payload discovery through target selection, therapeutic design, in vitro/in vivo characterization, optimization, candidate nomination, and IND-enabling studies.
- Ensure cross-functional integration with antibody discovery, chemistry, translational sciences, program management, CMC, and clinical development; represent the biology perspective.
- Monitor ADC technology developments and integrate relevant advancements into program strategies.
- Contribute to patent filings, publications, and external presentations.
- Prepare and review regulatory documents, including IND submissions, ensuring regulatory compliance.
Qualifications:
- Ph.D. in Cell Biology, Cancer Biology, Pharmacology, Chemical Biology, Biochemistry, Immunology, or related fields.
- 4+ years project leadership experience in biotech/pharmaceutical industry in preclinical drug development (immunology or oncology).
- Experience designing/interpreting in vitro and in vivo ADC assays (target expression/internalization, payload MoA, PK/PD, efficacy).
- Deep understanding of ADC design principles and the impact of target, antibody, and linker-payload properties on safety and efficacy.
Immunome seeks a cancer biologist to develop and champion novel therapeutic concepts and engineer next-generation ADC therapeutics by leveraging expertise in cancer biology, drug resistance mechanisms, and pharmacology. In partnership with cross-functional teams, lead the discovery, optimization, and nomination of new drug candidates for clinical development.
Responsibilities:
- Apply oncology and ADC pharmacology to formulate new therapeutic concepts.
- Lead preclinical discovery for novel ADC technologies: linker/payload discovery through target selection, therapeutic design, in vitro/in vivo characterization, optimization, candidate nomination, and IND-enabling studies.
- Ensure cross-functional integration with antibody discovery, chemistry, translational sciences, program management, CMC, and clinical development; represent the biology perspective.
- Monitor ADC technology developments and integrate relevant advancements into program strategies.
- Contribute to patent filings, publications, and external presentations.
- Prepare and review regulatory documents, including IND submissions, ensuring regulatory compliance.
Qualifications:
- Ph.D. in Cell Biology, Cancer Biology, Pharmacology, Chemical Biology, Biochemistry, Immunology, or related fields.
- 4+ years project leadership experience in biotech/pharmaceutical industry in preclinical drug development (immunology or oncology).
- Experience designing/interpreting in vitro and in vivo ADC assays (target expression/internalization, payload MoA, PK/PD, efficacy).
- Deep understanding of ADC design principles and the impact of target, antibody, and linker-payload properties on safety and efficacy.