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Principal Scientist

Scholar Rock
September 25, 2026
Full-time
Remote friendly (Cambridge, MA)
Worldwide
Clinical Research and Development
Role: Principal Scientist, Biomarker Development - provides scientific leadership for biomarker strategy and execution in neuromuscular disease programs. Responsibilities: develop and lead biomarker strategies; serve as a biomarker and translational science expert; guide assay development and data interpretation; collaborate across discovery, bioanalytical, and clinical teams; manage CROs and external labs; translate biological hypotheses into clinically actionable biomarker approaches. Requirements: PhD in skeletal muscle biology, immunology, neuroscience, pharmacology, or related field; 8+ years of biotech/pharma R&D experience with a focus on neuromuscular diseases; proven track record in biomarker discovery and development; expertise in immunoassays, bioinformatics, imaging, flow cytometry, and molecular assays; experience managing external collaborations. HighValue: neuromuscular disorder, biomarker discovery, preclinical and translational research, assay development, biologics/monoclonal antibodies, early clinical translation. WorkSetup: not specified, but role involves lab work, cross-functional collaboration, and CRO/vendor oversight.