Principal Research Scientist II, Gastroenterology, Immunology Discovery Research
AbbVie
August 27, 2026
Full-time
Remote friendly (Worcester, MA)
Worldwide
$268,500 - $268,500 USD yearly
Clinical Research and Development
Role: Scientific leader managing research in Gastroenterology/IBD within AbbVie's Immunology Discovery organization. Objectives include identifying and validating novel therapeutic targets, advancing drug candidates from early discovery to preclinical and first-in-human studies, and integrating cutting-edge scientific trends and patient-derived data. Responsibilities encompass leading a team of discovery scientists, overseeing assay development, in vitro/in vivo pharmacology studiesโincluding complex humanized modelsโand developing translational endpoints. The role requires fostering cross-functional and external collaborations, shaping research strategies, and communicating progress to senior stakeholders. Qualifications: PhD in Science with 8+ years (or Masterโs with 14+ years) of industry experience, extensive expertise in mucosal immunology, immuno- and non-immune cell biology, and proven success in progressing drug discovery programs. High-value specifics include deep knowledge of humanized CDVM models, immunology in autoimmune diseases, and experience managing multidisciplinary teams from early research through preclinical phases. The position emphasizes strategic leadership, scientific innovation, and effective matrix management. No explicit travel or remote work details provided.