Principal Research Scientist I, siRNA Synthesis & Analytical Development
AbbVie
June 27, 2026
On-site
Worcester, MA
$124,500 - $236,500 USD yearly
Clinical Research and Development
Responsibilities
- Lead the siRNA synthesis platform to support various stages of siRNA studies.
- Oversee solid-phase oligonucleotide synthesis, deprotection, purification, desalting, and analytical characterization of siRNA.
- Troubleshoot synthesis, purification, and analytical challenges to improve yield, purity, and scalability.
- Partner with cross-functional teams (siRNA screening, antibody conjugation, and CMC) to support platform and project objectives.
- Ensure rigorous documentation, data integrity, and compliance with internal quality standards.
- Track and evaluate emerging technologies and best practices in oligonucleotide and RNA-based therapeutics.
- Manage and develop a team of 2–3 scientists to deliver high-quality siRNA materials on time.
Qualifications
- BS, MS, or PhD in chemistry, chemical biology, biochemistry, or related field; typically 14+ (BS), 12+ (MS), or 6+ (PhD) years of biotech/pharma experience.
- Demonstrated expertise in siRNA synthesis, purification, and characterization.
- Strong knowledge of oligonucleotide chemistry, RNA chemistry, conjugation chemistry, and analytical techniques (HPLC, LC-MS, UV spectroscopy).
- Ability to independently address complex technical problems and drive projects.
- Excellent communication, collaboration, and organizational skills.
- Strong track record presenting complex scientific data to stakeholders.
- People management experience is a plus.
Benefits (if applicable)
- Paid time off; medical/dental/vision insurance; 401(k).
- Eligible for short-term and long-term incentive programs.
- Lead the siRNA synthesis platform to support various stages of siRNA studies.
- Oversee solid-phase oligonucleotide synthesis, deprotection, purification, desalting, and analytical characterization of siRNA.
- Troubleshoot synthesis, purification, and analytical challenges to improve yield, purity, and scalability.
- Partner with cross-functional teams (siRNA screening, antibody conjugation, and CMC) to support platform and project objectives.
- Ensure rigorous documentation, data integrity, and compliance with internal quality standards.
- Track and evaluate emerging technologies and best practices in oligonucleotide and RNA-based therapeutics.
- Manage and develop a team of 2–3 scientists to deliver high-quality siRNA materials on time.
Qualifications
- BS, MS, or PhD in chemistry, chemical biology, biochemistry, or related field; typically 14+ (BS), 12+ (MS), or 6+ (PhD) years of biotech/pharma experience.
- Demonstrated expertise in siRNA synthesis, purification, and characterization.
- Strong knowledge of oligonucleotide chemistry, RNA chemistry, conjugation chemistry, and analytical techniques (HPLC, LC-MS, UV spectroscopy).
- Ability to independently address complex technical problems and drive projects.
- Excellent communication, collaboration, and organizational skills.
- Strong track record presenting complex scientific data to stakeholders.
- People management experience is a plus.
Benefits (if applicable)
- Paid time off; medical/dental/vision insurance; 401(k).
- Eligible for short-term and long-term incentive programs.