Principal Research Scientist I, siRNA Platform Automation
AbbVie
August 10, 2026
Remote friendly (Worcester, MA)
United States
$124,500 - $236,500 USD yearly
Clinical Research and Development
Principal Research Scientist (siRNA)
Responsibilities:
- Establish and implement a high-throughput siRNA screening platform using automated liquid-handling systems.
- Serve as subject matter expert in siRNA screening experimental design, execution, and data interpretation.
- Lead siRNA optimization efforts (sequence design and novel chemical modifications) across multiple programs; mentor scientists.
- Generate hypotheses/proposals, improve screening workflows, and evaluate emerging siRNA technologies.
- Collaborate with internal siRNA teams and cross-functional collaborators to identify needs and enhance the platform and programs.
- Manage and develop a team of 2–3 scientists; provide technical guidance, mentorship, and day-to-day leadership.
Qualifications:
- BS/MS/PhD in Molecular Biology, Biochemistry, Chemical Biology, or related field; typically 6+ years (PhD), 12+ years (MS), or 14+ years (BS) relevant biotech/pharma experience.
- Proven siRNA design, in vitro screening, and potency assay experience using automated high-throughput platforms (e.g., Hamilton, Tecan).
- Experience with qRT-PCR, ELISA, and flow cytometry.
- Demonstrated cell culture experience (maintenance of diverse cell lines).
- Prior experience leading siRNA platform initiatives or portfolio programs.
- Plus: animal study design and downstream assays for genetic medicines.
- Exceptional interpersonal skills; strong presentation of complex scientific data. Plus: people management experience.
Benefits (if applicable): paid time off, medical/dental/vision insurance, 401(k), and eligibility for short- and long-term incentive programs.
Responsibilities:
- Establish and implement a high-throughput siRNA screening platform using automated liquid-handling systems.
- Serve as subject matter expert in siRNA screening experimental design, execution, and data interpretation.
- Lead siRNA optimization efforts (sequence design and novel chemical modifications) across multiple programs; mentor scientists.
- Generate hypotheses/proposals, improve screening workflows, and evaluate emerging siRNA technologies.
- Collaborate with internal siRNA teams and cross-functional collaborators to identify needs and enhance the platform and programs.
- Manage and develop a team of 2–3 scientists; provide technical guidance, mentorship, and day-to-day leadership.
Qualifications:
- BS/MS/PhD in Molecular Biology, Biochemistry, Chemical Biology, or related field; typically 6+ years (PhD), 12+ years (MS), or 14+ years (BS) relevant biotech/pharma experience.
- Proven siRNA design, in vitro screening, and potency assay experience using automated high-throughput platforms (e.g., Hamilton, Tecan).
- Experience with qRT-PCR, ELISA, and flow cytometry.
- Demonstrated cell culture experience (maintenance of diverse cell lines).
- Prior experience leading siRNA platform initiatives or portfolio programs.
- Plus: animal study design and downstream assays for genetic medicines.
- Exceptional interpersonal skills; strong presentation of complex scientific data. Plus: people management experience.
Benefits (if applicable): paid time off, medical/dental/vision insurance, 401(k), and eligibility for short- and long-term incentive programs.