Principal Research Scientist I - Cell/Mol Bio
AbbVie
1 month ago
On-site
Worcester, MA
Clinical Research and Development
Principal Research Scientist (Discovery Biotherapeutics and Genetic Medicine - BGM)
Job Responsibilities:
- Develop and optimize in vitro functional assays using ready-to-use cell line platforms and diverse signaling pathways to advance biotherapeutics discovery campaigns.
- Own screening funnel design and implementation for multiple biotherapeutic discovery programs; synthesize complex, multi-dimensional datasets into actionable insights for go/no-go decisions.
- Evaluate, pilot, and implement emerging cell line platforms, assay technologies, and laboratory automation solutions.
- Foster cross-functional collaborations with therapeutic area partners.
- Present and explain research findings and strategies; prepare scientific reports, publications, and presentations.
- Drive scientific excellence across multiple high-throughput projects and continuously improve automated workflows.
Qualifications:
- BS with 14+ years of experience, or MS with 12+ years, or PhD +6 years in Biology, Molecular and Cellular Biology, or related field.
- Extensive hands-on experience in high-throughput cell-based screening and biotherapeutic discovery; assay development using ready-to-use cell lines.
- Experience developing, optimizing, and executing high-throughput screening assays (cellular, immunoassays, functional readouts) at scale.
- Expertise with automated experimental platforms (robotics, liquid handlers, plate readers, imaging systems) and high-throughput data management.
- Ability to lead cross-functional research teams; manage complex, multi-site screening projects and communicate with stakeholders.
- Proficiency with enterprise data capture/analysis solutions (GeneData, Dotmatics, Benchling, or equivalent) and statistical/bioinformatics approaches for large datasets.
Desirable:
- Experience implementing and managing CRO partnerships for high-throughput screening.
- Hands-on experience with integrated lab automation platforms and workflow orchestration software.
- Track record of assay miniaturization, multiplexing, or novel cell line integration.
- Experience with machine learning or predictive analytics applied to screening data.
Benefits (as stated):
- Paid time off; medical/dental/vision insurance; 401(k).
- Eligible for short-term incentive programs.
Job Responsibilities:
- Develop and optimize in vitro functional assays using ready-to-use cell line platforms and diverse signaling pathways to advance biotherapeutics discovery campaigns.
- Own screening funnel design and implementation for multiple biotherapeutic discovery programs; synthesize complex, multi-dimensional datasets into actionable insights for go/no-go decisions.
- Evaluate, pilot, and implement emerging cell line platforms, assay technologies, and laboratory automation solutions.
- Foster cross-functional collaborations with therapeutic area partners.
- Present and explain research findings and strategies; prepare scientific reports, publications, and presentations.
- Drive scientific excellence across multiple high-throughput projects and continuously improve automated workflows.
Qualifications:
- BS with 14+ years of experience, or MS with 12+ years, or PhD +6 years in Biology, Molecular and Cellular Biology, or related field.
- Extensive hands-on experience in high-throughput cell-based screening and biotherapeutic discovery; assay development using ready-to-use cell lines.
- Experience developing, optimizing, and executing high-throughput screening assays (cellular, immunoassays, functional readouts) at scale.
- Expertise with automated experimental platforms (robotics, liquid handlers, plate readers, imaging systems) and high-throughput data management.
- Ability to lead cross-functional research teams; manage complex, multi-site screening projects and communicate with stakeholders.
- Proficiency with enterprise data capture/analysis solutions (GeneData, Dotmatics, Benchling, or equivalent) and statistical/bioinformatics approaches for large datasets.
Desirable:
- Experience implementing and managing CRO partnerships for high-throughput screening.
- Hands-on experience with integrated lab automation platforms and workflow orchestration software.
- Track record of assay miniaturization, multiplexing, or novel cell line integration.
- Experience with machine learning or predictive analytics applied to screening data.
Benefits (as stated):
- Paid time off; medical/dental/vision insurance; 401(k).
- Eligible for short-term incentive programs.