Principal Research Scientist I
AbbVie
August 20, 2026
Remote friendly (North Chicago, IL)
United States
$124,500 - $236,500 USD yearly
Clinical Research and Development
Purpose
- Support discovery-stage programs across therapeutic areas within preclinical safety using in silico, in vitro, and in vivo tools to design and execute a safety assessment strategy that advances the pipeline.
- Work cross-functionally as a project toxicologist, providing subject matter expertise and data integration.
Responsibilities
- Design and execute project-specific safety strategies using internal/external resources, in silico tools, in vitro models, and in vivo studies; select and design decision-enabling experiments.
- Develop and deploy in vitro safety assessment tools (simple/complex models or NAMs) and apply appropriate endpoints (e.g., imaging, toxicogenomics) to support decisions.
- Identify and resolve key project hurdles using available information/resources.
- Communicate with cross-functional teams and leadership to align on program strategy.
- Incorporate new literature information into individual projects and the overall safety assessment strategy.
- Pursue project-relevant exploration to support data-driven decision-making.
- May mentor/supervise team members and evaluate performance; accountable for effective team performance.
- Collaborate with other teams to identify scientific advancement and efficiency opportunities.
Qualifications
Required
- Bachelor’s (14+ years) or Master’s (12 years) or PhD (6+ years).
- Experience directing and interpreting in vitro safety study data.
- Ability to function independently and generate original research/development strategies.
- Thorough theoretical and practical understanding of own scientific discipline.
- Effective writing and research communication; strong presentation skills.
Preferred
- People leadership/management experience.
- DABT board certification or equivalent.
- Experience on cross-functional pharmaceutical development project teams.
- Support discovery-stage programs across therapeutic areas within preclinical safety using in silico, in vitro, and in vivo tools to design and execute a safety assessment strategy that advances the pipeline.
- Work cross-functionally as a project toxicologist, providing subject matter expertise and data integration.
Responsibilities
- Design and execute project-specific safety strategies using internal/external resources, in silico tools, in vitro models, and in vivo studies; select and design decision-enabling experiments.
- Develop and deploy in vitro safety assessment tools (simple/complex models or NAMs) and apply appropriate endpoints (e.g., imaging, toxicogenomics) to support decisions.
- Identify and resolve key project hurdles using available information/resources.
- Communicate with cross-functional teams and leadership to align on program strategy.
- Incorporate new literature information into individual projects and the overall safety assessment strategy.
- Pursue project-relevant exploration to support data-driven decision-making.
- May mentor/supervise team members and evaluate performance; accountable for effective team performance.
- Collaborate with other teams to identify scientific advancement and efficiency opportunities.
Qualifications
Required
- Bachelor’s (14+ years) or Master’s (12 years) or PhD (6+ years).
- Experience directing and interpreting in vitro safety study data.
- Ability to function independently and generate original research/development strategies.
- Thorough theoretical and practical understanding of own scientific discipline.
- Effective writing and research communication; strong presentation skills.
Preferred
- People leadership/management experience.
- DABT board certification or equivalent.
- Experience on cross-functional pharmaceutical development project teams.