Principal Programmer, Statistical Programming (Remote)
Vertex Pharmaceuticals
August 25, 2026
Remote friendly (Boston, MA)
United States
Clinical Research and Development
General Summary:
The Principal Statistical Programmer works with management to delegate tasks appropriately, track progress, and provide expert technical support to team members. Serves as a project lead Statistical Programmer within designated clinical sub-team(s).
Key Duties and Responsibilities:
- Use advanced features of SAS, including interfacing with other software applications and operating system tools
- Perform quality control checks of SAS code and outputs produced by other Statistical Programmers
- Demonstrate in-depth knowledge of clinical development and medical data
- Solve complex clinical trial reporting problems; provide technical support and exercise judgment to ensure accurate, timely study tasks
- Collaborate with Statistical Programmers, Biostatisticians, Data Management, and other submission-related departments (often with Senior Management)
- Create files, documents, and analyses needed for eCTD electronic submissions, including ISS/ISE
- Provide leadership to ensure compliance with Vertex SOPs and FDA/ICH/GCP regulations
- Create, review, and approve documentation supporting data analysis, reporting, and CDISC data submissions
- Participate in cross-functional project teams for SOPs, guidelines, process improvements, system validation/acquisition, customization, and integration of new tools
Knowledge and Skills:
- Proficiency in SAS (Macro language, BASE SAS, SAS/STAT, SAS/GRAPH)
- Intermediate knowledge of CDISC standards and clinical trials
- Regulatory submission experience
- Effective written and verbal communication
Education and Experience:
- Bachelor’s degree in a scientific discipline
- Typically 5+ years (M.S. or above) or 8+ years (B.S.) in biotech, pharmaceuticals, or a Clinical Research Organization
Benefits/Compensation (as stated): Eligible for annual bonus and annual equity awards; some roles may be eligible for overtime pay.
The Principal Statistical Programmer works with management to delegate tasks appropriately, track progress, and provide expert technical support to team members. Serves as a project lead Statistical Programmer within designated clinical sub-team(s).
Key Duties and Responsibilities:
- Use advanced features of SAS, including interfacing with other software applications and operating system tools
- Perform quality control checks of SAS code and outputs produced by other Statistical Programmers
- Demonstrate in-depth knowledge of clinical development and medical data
- Solve complex clinical trial reporting problems; provide technical support and exercise judgment to ensure accurate, timely study tasks
- Collaborate with Statistical Programmers, Biostatisticians, Data Management, and other submission-related departments (often with Senior Management)
- Create files, documents, and analyses needed for eCTD electronic submissions, including ISS/ISE
- Provide leadership to ensure compliance with Vertex SOPs and FDA/ICH/GCP regulations
- Create, review, and approve documentation supporting data analysis, reporting, and CDISC data submissions
- Participate in cross-functional project teams for SOPs, guidelines, process improvements, system validation/acquisition, customization, and integration of new tools
Knowledge and Skills:
- Proficiency in SAS (Macro language, BASE SAS, SAS/STAT, SAS/GRAPH)
- Intermediate knowledge of CDISC standards and clinical trials
- Regulatory submission experience
- Effective written and verbal communication
Education and Experience:
- Bachelor’s degree in a scientific discipline
- Typically 5+ years (M.S. or above) or 8+ years (B.S.) in biotech, pharmaceuticals, or a Clinical Research Organization
Benefits/Compensation (as stated): Eligible for annual bonus and annual equity awards; some roles may be eligible for overtime pay.