Principal Process Engineer - Purification, Lilly Medicine Foundry

Role: Principal Process Engineer supporting GMP manufacturing of biologics, peptides, oligonucleotides, and bioconjugates at a new Lilly API production facility. Responsibilities: develop, optimize, and sustain purification processes; perform impact and risk assessments of equipment; support equipment qualification and commissioning; mentor junior engineers; ensure compliance with cGMP and quality standards; collaborate across departments including automation, quality, and operations; author technical reports and support regulatory submissions. Requirements: BS/MS in chemical engineering or related field; minimum 5 years' experience in pharmaceutical or biotech process engineering supporting API manufacturing, particularly in biologics or peptides; strong knowledge of chromatography, TFF, and other unit operations; familiarity with process control systems such as DeltaV; excellent troubleshooting, analytical, and communication skills. Preferences: deep technical expertise in purification equipment and control strategies; experience with software packages like Aspen or Rockwell; proven leadership and mentoring capability. High-Value: biologics, peptides, oligonucleotides, GMP API manufacturing, equipment qualification, process optimization, cross-functional collaboration, startup environment for a greenfield site. Work setup: initial at Lilly Technology Center, Indianapolis, with permanent operation at the Lebanon, Indiana facility; on-site with flexibility for business needs.