Principal Process Engineer, Lilly Medicine Foundry
Eli Lilly and Company
August 13, 2026
On-site
Indianapolis, IN
Operations
Responsibilities:
- Provide technical assessment and support for production operations for process knowledge, process/equipment support, process optimization, equipment capability/asset management, and engineering business systems for small molecule API manufacturing.
- Perform impact and risk assessments for unit operations.
- Learn reactor lab/plant design including automation recipes and procedures.
- Ensure safety of people/environment and compliance with safety policies.
- Ensure processing equipment complies with internal Quality System requirements, applicable engineering standards, and cGMP.
- Assess scale-up/rig fit via technical data package review and modeling/simulations and/or experimental work to ensure acceptable heat/mass transfer.
- Engage and communicate with HSE, Quality Assurance, Tech Services, Development, Operations, FUME/C&Q, Automation, Maintenance, Environmental Monitoring, and Manufacturing.
- Author/review/approve technical reports and regulatory submissions; maintain adequate records and technical notebooks.
- Identify quality issues proactively and communicate appropriately.
- Develop/review plans and timetables for project work.
Basic Requirements:
- BS or MS in Chemical Engineering or related discipline.
- Minimum 4 years’ experience in pharmaceutical/biotech/chemical manufacturing/CMO or other relevant batch manufacturing.
- Authorized to work in the U.S. full-time; no visa sponsorship.
Additional Preferences:
- Experience with API/intermediates manufacturing or development.
- Unit operations knowledge (e.g., reactions, distillation, phase separation, filtration, drying).
- Software: DeltaV, Dynochem, Aspen, and/or electronic lab notebooks.
- Strong analytical/problem-solving and communication skills.
- Understanding of process control systems.
Benefits:
- Full-time employees may be eligible for a company bonus; comprehensive benefits including 401(k), pension, vacation, medical/dental/vision, life insurance, time off/leave, and well-being benefits.
Location:
- Initial: Lilly Technology Center (Indianapolis) or Parkwood West (Carmel); Permanent: Lilly Medicines Foundry (Lebanon, IN).
- Provide technical assessment and support for production operations for process knowledge, process/equipment support, process optimization, equipment capability/asset management, and engineering business systems for small molecule API manufacturing.
- Perform impact and risk assessments for unit operations.
- Learn reactor lab/plant design including automation recipes and procedures.
- Ensure safety of people/environment and compliance with safety policies.
- Ensure processing equipment complies with internal Quality System requirements, applicable engineering standards, and cGMP.
- Assess scale-up/rig fit via technical data package review and modeling/simulations and/or experimental work to ensure acceptable heat/mass transfer.
- Engage and communicate with HSE, Quality Assurance, Tech Services, Development, Operations, FUME/C&Q, Automation, Maintenance, Environmental Monitoring, and Manufacturing.
- Author/review/approve technical reports and regulatory submissions; maintain adequate records and technical notebooks.
- Identify quality issues proactively and communicate appropriately.
- Develop/review plans and timetables for project work.
Basic Requirements:
- BS or MS in Chemical Engineering or related discipline.
- Minimum 4 years’ experience in pharmaceutical/biotech/chemical manufacturing/CMO or other relevant batch manufacturing.
- Authorized to work in the U.S. full-time; no visa sponsorship.
Additional Preferences:
- Experience with API/intermediates manufacturing or development.
- Unit operations knowledge (e.g., reactions, distillation, phase separation, filtration, drying).
- Software: DeltaV, Dynochem, Aspen, and/or electronic lab notebooks.
- Strong analytical/problem-solving and communication skills.
- Understanding of process control systems.
Benefits:
- Full-time employees may be eligible for a company bonus; comprehensive benefits including 401(k), pension, vacation, medical/dental/vision, life insurance, time off/leave, and well-being benefits.
Location:
- Initial: Lilly Technology Center (Indianapolis) or Parkwood West (Carmel); Permanent: Lilly Medicines Foundry (Lebanon, IN).