Principal Manager, Clinical Operations Lead

Role: Principal Manager, Clinical Operations Lead overseeing US regional clinical trials in cancer immunotherapy programs, focusing on PRAME-targeted therapies, including TCR T-cell therapies and bispecifics. Responsibilities: lead trial execution from start-up through completion, oversee CROs and vendors, manage cross-functional collaborations across Clinical Development, Regulatory, Safety, Biometrics, and Supply Chain; ensure compliance, timelines, and budgets; drive risk mitigation, SOP development, process improvements, and operational excellence; mentor junior team members. Requirements: Bachelor's degree in life sciences or nursing; 7+ years in global clinical operations, especially in late-phase or launch settings within oncology; experience with cell/gene therapies or complex biologics preferred. Skills: strong leadership in trial management, vendor oversight, cross-functional collaboration, problem-solving, and operational design. High-Value: focus on late-stage oncology, biologics, cell and gene therapies, with global trial oversight and vendor management. Work setup: fully remote in the US; no travel specified.