Principal Investigator / Sr. Principal Investigator, Clinical Pharmacology & Pharmacometrics

Role: Lead clinical pharmacologist specializing in PBPK modeling within Incyte's Clinical and Quantitative Pharmacology team, supporting drug development from IND through Phase IV. Responsibilities: develop and implement clinical pharmacology strategies across programs, interpret pharmacometric analyses to inform dose and formulation decisions, design and verify PBPK models using platforms like Simcyp or GastroPlus, and collaborate with cross-functional teams including DMPK, pharmacology, clinical development, regulatory, and medical affairs. Contribute to regulatory submissions, author reports, and stay current with scientific advances. Qualifications: Ph.D. or MD with 3-10+ years industry experience in clinical pharmacology, strong expertise in PBPK modeling, proficiency with modeling tools (GastroPlus, Simcyp, R, Matlab), and experience supporting clinical development and regulatory interactions. High-value specifics: focus on drug disposition, DDI prediction, formulation optimization, and model-informed drug development; involvement in preclinical to post-market phases; cross-functional collaboration with scientific and regulatory teams. Work setup: not specified; emphasis on scientific leadership and modeling expertise.