Principal Engineer, Lentivirus Downstream Process Development

Role: Principal Engineer in Lentivirus Downstream Process Development, leading the design, optimization, and scale-up of purification processes for lentiviral vectors in cell therapy. Responsibilities: develop mechanistic and AI-driven models for downstream processing (clarification, chromatography, TFF), translate bench-scale work to GMP manufacturing, implement advanced process control strategies, troubleshoot, ensure regulatory compliance, and collaborate with upstream and analytical teams. Requirements: PhD or MS in Chemical/Biomedical Engineering or related field; 8+ (PhD) or 10+ (MS) years in bioprocessing or manufacturing within biotech/pharma; expertise in bioprocess modeling, chromatography, TFF, GMP/CMC regulations, and lentiviral vector technologies. Preferred: experience with large-scale (>50L) vector purification, in vivo CAR-T processes, Python/MATLAB, and cross-functional collaboration. High-value biopharma specifics: focus on viral vector processes, GMP manufacturing, early- to late-phase clinical development, and integration of automation and analytics for gene/cell therapies. Work setup: based in Somerset, NJ, with leadership responsibilities in process development for innovative cell therapy programs.