Principal Associate Scientist, Target Validation for Nucleic Acid Therapeutics

Role Summary

Principal Associate Scientist, Target Validation for Nucleic Acid Therapeutics — Onsite in Cambridge, MA. Join an interdisciplinary team to broaden the oligonucleotide platform and extrahepatic siRNA delivery through in vitro and in vivo mechanistic studies. Detail-oriented, able to multi-task and learn new techniques in oligonucleotides; thrives in a goal-driven, deadline-driven environment.

Responsibilities

• Engage in investigative and mechanistic research to evaluate RNAi and other oligonucleotide activity using biochemical and cell/molecular biology assays.
• Quantify oligonucleotide therapeutics, mRNA, and protein levels in cell and tissue models.
• Learn and execute new techniques to support in vitro and in vivo studies.
• Design, troubleshoot, and interpret experiments.
• Prepare clearly articulated experimental reports and data presentations for diverse audiences.

Qualifications

• BS/MS in Biology, Cell/Molecular Biology, Biochemistry or related field with 5‚Äì8 years of work experience, preferably in an industrial setting.
• Proficiency in mammalian cell culture (maintenance, transfection, etc.).
• Proficiency in molecular biology assays for RNA/DNA/protein quantification (qPCR, dPCR, Western blotting, ELISA, immunoprecipitations).
• Prior experience with in vivo rodent studies, including subcutaneous and IV dosing, retro-orbital bleeding, and tissue dissections.
• Previous experience with oligonucleotide therapeutics (ASOs, siRNAs, etc.) desired.
• Familiarity with muscle and cardiac pathophysiology and muscle/cardiac in vitro models preferred.
• Excellent lab technique and ability to work independently.
• Strong interpersonal and excellent written and oral communication skills.

Education

• Not specified beyond degree requirements above.