Principal Associate Scientist, Target Validation for Nucleic Acid Therapeutics
Alnylam PharmaceuticalsWant to see how your resume matches up to this job? A free trial of our JobsAI will help! With over 2,000 biopharma executives loving it, we think you will too! Try it now — JobsAI.
Role Summary
Principal Associate Scientist, Target Validation for Nucleic Acid Therapeutics: The Research Department at Alnylam is seeking an experienced Principal Associate Scientist to join an interdisciplinary team dedicated to broadening our oligonucleotide platform and extrahepatic siRNA delivery through in vitro and in vivo mechanistic studies. The role requires strong interpersonal skills, the capacity to multi-task, and the ability to learn and master new techniques in the field of oligonucleotides. We particularly seek someone who is detail-oriented and who will flourish in a goal-driven team environment under tight deadlines. This onsite position will be located at 675 W Kendall St, Cambridge, MA.
Responsibilities
- This candidate will engage in investigative and mechanistic research efforts to evaluate RNAi and other oligonucleotide compound activity by applying biochemical and cell/molecular biology assays.
- Quantify oligonucleotides therapeutics/mRNA/protein levels in cell and tissue models.
- Willingness to learn and execute new techniques to support in vitro and in vivo studies.
- Design, troubleshoot and interpret experiments.
- Prepare clearly articulated experimental reports and data presentations for a variety of audiences.
Qualifications
- BS/MS in Biology, Cell/Molecular Biology, Biochemistry or related field with 5-8 years of work experience, preferably in an industrial setting.
- Proficiency in mammalian cell culture (maintenance, transfection, etc.).
- Proficiency in molecular biology assays for RNA/DNA/protein quantification (qPCR, dPCR, Western blotting, ELISA, immunoprecipitations).
- Prior experience conducting and/or interpreting in vivo rodent studies, including subcutaneous and IV dosing, retro-orbital bleeding, and tissue dissections.
- Previous experience with oligonucleotide therapeutics (ASOs, siRNAs, etc.) desired.
- Familiarity with muscle and cardiac pathophysiology and muscle/cardiac in vitro models preferred.
- Excellent lab technique and ability to work independently.
- Strong interpersonal skills and excellent communication skills (written and oral) are required.