Principal Associate Scientist, In Vivo Pharmacology

Overview:

The Research Department at Alnylam is seeking a passionate and experienced Principal Associate Scientist to join our dynamic, fast-paced and interdisciplinary in vivo Pharmacology team within the RNAi Discovery Platform group.

The successful candidate will bring a robust and broad technical skillset and possess a deep scientific understanding of animal research and molecular biology. The role will require strong interpersonal and organizational skills, the capacity to multi-task, and the ability to learn, master, and share new techniques. We particularly seek someone who is detail-oriented and who will flourish in a goal-driven team environment under tight deadlines and balancing multiple projects. This individual will join a dynamic and highly collaborative team. Experience and passion for working with animals is a must.

This role is considered On-Site.

Summary of Key Responsibilities:

• Design and execute in vivo studies to evaluate and characterize molecules for RNAi therapeutic delivery to a diverse array of tissues in a variety of animal models.
• Conduct in vivo procedures in mice and rats, including therapeutic administration using established methodologies and comprehensive tissue collections and dissections.
• Develop novel in vivo procedures and molecular assays, establish SOPs and train staff.
• Conduct and troubleshoot assays such as qPCR, western blot, ELISA, and imaging to support in vivo studies.
• Maintain safe and clean working environment by complying with procedures, rules, and regulations.
• Responsible for data entry and independent data analysis in timely, high-quality manner.
• Prepare clearly articulated experimental reports and data presentations in group meetings as well as to broader audiences.
• Adapt quickly to changing priorities in a dynamic work environment.
• Effectively and proactively multi-task and operate in a team-based environment.
• Communicate openly and directly within and across teams and management and demonstrate the ability to effectively manage conflict.

Qualifications:

• BS/MS in Biology, Animal/Veterinary Sciences, Cell/Molecular Biology, Biochemistry, or related field with 4-8 years of post-degree research experience in an industrial or academic setting working with animals.
• Excellent lab techniques and the ability to analyze, interpret, and present data and work independently are a prerequisite.
• In vivo experience with rodents, including routine animal handling, multiple routes of dose administration, blood collection, dissection techniques, and necropsies.
• Experience in specialized in vivo techniques such as direct tissue injections or collections (IT, ICV, ICM, IVT, IA, OP, PO etc.) is a plus.
• Experience designing and running in vivo imaging (IVIS) studies is a plus.
• Experience in molecular biology techniques including RNA/DNA/protein extraction, qPCR, Western blot, ELISA.
• Ability to follow SOP, execute, analyze, interpret, and troubleshoot experiments.
• Excellent organization, documentation, and record-keeping (compliance with ELN (Electronic Lab Notebook) guidelines) are required.
• Must thrive in a team environment and possess excellent communication skills (both written and oral).

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.