Precision Medicine Technology Portfolio Sr. Manager

Role Summary

Precision Medicine Technology Portfolio Sr. Manager is responsible for strategic leadership and operational oversight of a portfolio of technology capabilities that enable Amgen’s Precision Medicine strategy. This role partners with Translational Sciences, Biospecimen Management, Clinical Operations, and multiple Technology teams to define future-state needs, shape the technology roadmap, and guide delivery of high-value solutions.

Responsibilities

• Lead the coordination and ongoing refinement of the Precision Medicine technology portfolio - orchestrating alignment between business needs and technology capacity, including investment prioritization, resource planning, and performance measurement.
• Establish and manage PMed portfolio governance routines that enable clear decision-making and alignment across scientific and technology partners.
• Maintain a multi-year technology roadmap that reflects scientific strategy, operational needs, and emerging external trends.
• Translate scientific and translational use cases into actionable technology requirements, in partnership with Technology Business Analysts.
• Partner with scientific and operational groups to understand problems, find opportunities, and ensure business needs are articulated to enable technology solutions supporting end-to-end biospecimen, biomarker, and data workflows.
• Collaborate with technology architects and product teams to evaluate solutions, ensure interoperability, and support long-range architecture planning.
• Facilitate project intake, scoping, and prioritization in alignment with strategic objectives.
• Support delivery teams through requirements clarification, risk identification, and cross-functional alignment.
• Project management for high-value, business critical projects.
• Develop and maintain portfolio-level KPIs and reporting to track value, health, and delivery progress.
• Develop and maintain RACI to ensure effective partnerships across critical multi-functional activities.
• Drive communication and change management strategies to ensure adoption of new capabilities across scientific teams.
• Partner with stakeholders to assess readiness, support training, and ensure technologies integrate seamlessly into scientific workflows.
• Serve as a strategic connector across Precision Medicine, Translational Sciences, Clinical Operations, CfDA, Enterprise and R&D Technology, Data and Analytics, and Governance functions.
• Prepare and deliver concise, decision-ready materials for senior leadership engagement.

Qualifications

• Required: Doctorate degree and 2 years of relevant experience
• Required: OR Master‚Äôs degree and 4 years of relevant experience
• Required: OR Bachelor‚Äôs degree and 6 years of relevant experience
• Required: OR Associate‚Äôs degree and 10 years of relevant experience
• Required: OR High school diploma / GED and 12 years of relevant experience
• Preferred: Experience working at the interface of science and technology within a biopharma or life sciences environment
• Preferred: Proven ability to lead portfolio management, strategic planning, or enterprise technology governance
• Preferred: Working knowledge of translational science, biospecimen lifecycle management, biomarker technologies, or related R&D domains
• Preferred: Understanding of data architectures, digital lab technologies, and informatics platforms supporting translational and clinical workflows
• Preferred: Strong critical thinking, systems thinking, and problem-solving capabilities
• Preferred: Ability to influence and collaborate effectively in a highly matrixed environment
• Preferred: Excellent written and verbal communication skills, with experience preparing executive-level materials
• Preferred: Demonstrated ability to inspire change, support adoption of new technologies, and manage competing priorities

Education

• Doctorate required with 2+ years of relevant experience; Master‚Äôs required with 4+ years; Bachelor‚Äôs required with 6+ years; Associate‚Äôs required with 10+ years; High school/GED with 12+ years