Precision Medicine Director – Obesity & Cardiometabolic Disorders

Role Summary

Precision Medicine Director – Obesity & Cardiometabolic Disorders. Lead translational and precision medicine strategies for early-stage assets, guiding them from Discovery through IND-enabling studies and into first-in-human trials. Serve as a translational thought leader, integrating scientific insights with strategic decision-making to advance therapies in obesity and cardiometabolic care.

Responsibilities

• Biomarker & Data Strategy: Design and lead phase-appropriate biomarker strategies to support preclinical decision-making and enable first-in-human trials. Leverage high-dimensional datasets to refine patient-selection hypotheses and deepen understanding of target biology.
• Strategic Leadership in Early Development: Build scientifically rigorous biomarker strategies that advance preclinical assets toward clinical testing; embed biomarker, MoA, and patient-selection hypotheses early in development.
• Integration Across Discovery and Early Clinical Development: Serve as the translational medicine bridge between research and clinical development to achieve clinical readiness and early proof-of-concept.
• Mechanistic and Reverse Translational Focus: Champion reverse translational strategies to investigate disease heterogeneity and resistance; develop actionable hypotheses around disease biology and patient subpopulations.
• Cross-Functional Collaboration: Partner with Discovery Research, Clinical Pharmacology, Toxicology, Early Development, and Regulatory Affairs to ensure progression from IND-enabling activities to FIH studies.
• External Innovation & Partnerships: Identify and cultivate collaborations with academic institutions, consortia, and biotech companies; maintain a leadership role in the external scientific community.
• TA-Level Strategic Contributions: Provide scientific input into broader therapeutic area strategies, including target portfolio prioritization and exploration of combination therapies.
• Mentorship and Team Leadership: Mentor and provide strategic oversight to a team of biomarker scientists and on project teams.

Qualifications

• Basic Qualifications:
  • Doctorate degree and 4 years of relevant industry or academic experience
  • OR Master’s degree and 7 years of relevant experience
  • OR Bachelor’s degree and 9 years of relevant experience
• Preferred Qualifications:
  • PhD or MD/PhD with 6+ years in translational research in biopharmaceuticals, with focus on metabolic or cardiometabolic diseases; obesity research strongly preferred
  • Leadership as Project Team Lead for cardiometabolic or obesity programs from early research through IND
  • Experience as biomarker lead on clinical-stage assets with deep obesity biology, insulin resistance, dyslipidemia, and cardiovascular pathophysiology expertise
  • Publications/presentations or leadership roles in relevant forums
  • Expertise in biomarker discovery/validation, multi-omics-driven stratification, and patient segmentation
  • Ability to integrate complex data to support development decisions; strong translational science curiosity
  • Proven ability to influence across cross-functional, matrixed organizations without direct authority
  • Leadership experience mentoring a team of junior Precision Medicine Scientists

Skills

• Translational medicine and biomarker strategy
• Multi-omics data interpretation (genomics, proteomics, single-cell data)
• Cross-functional collaboration and leadership
• Strategic decision-making in early development
• Mentorship and team leadership

Education

• Doctorate, or Master’s, or Bachelor’s degree as referenced in Basic Qualifications

Additional Requirements

• Travel: Not specified
• Physical demands: Not specified