Precision Medicine Director – Obesity & Cardiometabolic Disorders

Role Summary

Precision Medicine Director – Obesity & Cardiometabolic Disorders. Lead translational and precision medicine strategies for early-stage assets in obesity and cardiometabolic disorders, guiding from discovery through IND-enabling studies and into first-in-human trials. Integrate scientific insights with strategic decision-making to drive biomarker discovery, patient selection, and mechanism-of-action exploration.

Responsibilities

• Biomarker & Data Strategy: Design and lead phase-appropriate biomarker strategies to support preclinical decision-making and enable FIH trials; leverage high-dimensional datasets to refine patient-selection hypotheses.
• Strategic Leadership in Early Development: Build mechanistically informed biomarker strategies to advance assets toward clinical testing; embed hypotheses early in development to inform clinical decisions.
• Integration Across Discovery and Early Clinical Development: Act as translational bridge between research and clinical development to achieve readiness and early proof-of-concept.
• Mechanistic and Reverse Translational Focus: Champion reverse translational strategies to investigate heterogeneity, resistance, and biomarker discovery; generate actionable hypotheses on biology and patient subpopulations.
• Cross-Functional Collaboration: Partner with Discovery Research, Clinical Pharmacology, Toxicology, Early Development, and Regulatory Affairs to ensure progression from IND-enabling activities to FIH.
• External Innovation & Partnerships: Cultivate collaborations with academia, consortia, and industry; maintain thought leadership in obesity and cardiometabolic disorders.
• TA-Level Strategic Contributions: Inform broader therapeutic area strategies, including target portfolio prioritization and exploration of combinations.
• Mentorship and Team Leadership: Mentor and oversee a team of biomarker scientists.

Qualifications

• What We Expect Of You: Doctorate with 4+ years of relevant experience, or Master‚Äôs with 7+ years, or Bachelor‚Äôs with 9+ years.
• Preferred Qualifications:
  • PhD or MD/PhD with 6+ years in translational research in biopharma, with focus on metabolic/cardiometabolic diseases; obesity experience strongly preferred.
  • Experience as Project Team Lead for cardiometabolic or obesity programs from early research through IND submission.
  • Extensive experience as a biomarker lead on clinical-stage assets with deep obesity biology, insulin resistance, dyslipidemia, and cardiovascular pathophysiology expertise.
  • Published or presented in relevant forums; strong biomarker discovery/validation and multi-omics-driven stratification experience.
  • Ability to integrate complex data to inform development decisions; strong translational science curiosity.
  • Proven ability to influence cross-functional, matrixed teams without direct authority; leadership of junior Precision Medicine Scientists.

Skills

• Biomarker discovery and validation
• Multi-omics data interpretation
• Translational medicine strategy and leadership
• Cross-functional collaboration and project leadership
• Strong communication and stakeholder management

Education

• PhD or MD/PhD preferred for advanced qualifications
• Relevant advanced degree with demonstrated translational research experience