Postdoctoral Scientist - Neurodegeneration
Eli Lilly and Company
August 29, 2026
On-site
Boston, MA
Clinical Research and Development
Postdoctoral Scientist — Neurodegeneration
Responsibilities:
- Establish seed and preformed fibril (PFF)-based amyloid forming protein pathology models in a human iPSC-derived tri-culture system (neurons, astrocytes, microglia), characterizing seeding efficiency, aggregate formation, and timing parameters.
- Perform mono- vs. co- vs. tri-culture comparisons to quantify multicellular gain in neurotoxicity and neuroinflammatory responses.
- Characterize microglial activation and cytokine release profiles (multiplex MSD cytokine profiling) and neurotoxicity in response to pathological insults.
- Execute a species-ranking study comparing monomers, oligomers, and fibrillar preparations for neurotoxic and neuroinflammatory potency.
- Evaluate tool compounds (siRNAs, antibodies) and internal proprietary compounds for potency, cellular uptake, and safety in healthy vs. pathological tri-culture.
- Generate paired healthy vs. disease-context datasets to compare compound behavior and support LRL neurodegeneration programs.
- Publish as first author and present findings internally and externally.
Basic Requirements:
- PhD in Neuroscience, Cell Biology, Molecular Biology, or closely related field.
- Hands-on experience with iPSC culture and/or primary neuron culture.
- In vitro neurodegenerative disease modeling experience (e.g., PFF seeding, protein aggregation assays, amyloid forming protein biology).
Additional Skills/Preferences:
- Neuronal co- or tri-culture experience with glia (astrocytes and/or microglia).
- High-content imaging, immunofluorescence (ICC-IF), and image analysis pipeline proficiency.
- Neuroinflammation assays experience with multiplex cytokine profiling (e.g., MSD, Luminex).
- CNS therapeutic modality assessment experience (siRNAs, antibodies, small molecules in cell assays).
- Ability to independently design, execute, and troubleshoot multi-parametric cell-based experiments.
- Peer-reviewed publications; collaborative, translational industry mindset.
Responsibilities:
- Establish seed and preformed fibril (PFF)-based amyloid forming protein pathology models in a human iPSC-derived tri-culture system (neurons, astrocytes, microglia), characterizing seeding efficiency, aggregate formation, and timing parameters.
- Perform mono- vs. co- vs. tri-culture comparisons to quantify multicellular gain in neurotoxicity and neuroinflammatory responses.
- Characterize microglial activation and cytokine release profiles (multiplex MSD cytokine profiling) and neurotoxicity in response to pathological insults.
- Execute a species-ranking study comparing monomers, oligomers, and fibrillar preparations for neurotoxic and neuroinflammatory potency.
- Evaluate tool compounds (siRNAs, antibodies) and internal proprietary compounds for potency, cellular uptake, and safety in healthy vs. pathological tri-culture.
- Generate paired healthy vs. disease-context datasets to compare compound behavior and support LRL neurodegeneration programs.
- Publish as first author and present findings internally and externally.
Basic Requirements:
- PhD in Neuroscience, Cell Biology, Molecular Biology, or closely related field.
- Hands-on experience with iPSC culture and/or primary neuron culture.
- In vitro neurodegenerative disease modeling experience (e.g., PFF seeding, protein aggregation assays, amyloid forming protein biology).
Additional Skills/Preferences:
- Neuronal co- or tri-culture experience with glia (astrocytes and/or microglia).
- High-content imaging, immunofluorescence (ICC-IF), and image analysis pipeline proficiency.
- Neuroinflammation assays experience with multiplex cytokine profiling (e.g., MSD, Luminex).
- CNS therapeutic modality assessment experience (siRNAs, antibodies, small molecules in cell assays).
- Ability to independently design, execute, and troubleshoot multi-parametric cell-based experiments.
- Peer-reviewed publications; collaborative, translational industry mindset.