Postdoctoral Scientist – Gene Therapy Biodistribution & Molecular Biology (CNS)
Eli Lilly and Company
June 26, 2026
On-site
Boston, MA
Clinical Research and Development
Position Overview
- Postdoctoral Scientist, Drug Delivery and Connected Systems (DDCS): CNS gene therapy biodistribution and molecular bioanalysis to support translational advancement of viral and non-viral gene therapy for neurological/neurodegenerative diseases.
Key Responsibilities
- Lead design, development, optimization, and execution of biodistribution assays for AAVs, LNPs, siRNA distribution, transgene expression, and persistence across CNS and peripheral tissues.
- Apply vector biology/AAV serotype-specific biodistribution knowledge (e.g., AAV9, AAVrh10, PHP.eB).
- Use molecular/bioanalytical methods: PCR/qPCR/ddPCR, stem-loop PCR, vg/dg quantification; ELISA/immunoassays; LC–MS (as applicable); IHC and spatial tissue analyses; NGS for tracking/expression/integration.
- Ensure assays are fit-for-purpose (sensitive/reproducible) and aligned to translational objectives; conduct off-target analysis and DRG toxicology assay development.
- Independently design and troubleshoot CNS biodistribution studies using DoE/DOR; maintain rigorous documentation.
- Integrate biodistribution with PK/PD to guide dose/route/therapeutic index; link readouts to functional/anatomical/disease endpoints.
- Interface with external CROs and provide oversight for in vivo studies and molecular analyses.
- Analyze and visualize large datasets; communicate findings.
Basic Requirements
- PhD in Molecular Biology/Biochemistry/Pharmacology/Neuroscience/Bioengineering or related.
- In-depth AAV biodistribution and/or molecular bioanalytical assay development.
- Hands-on PCR/qPCR/ddPCR, ELISA, IHC, NGS, and/or related techniques.
- Solid CNS gene therapy/tissue biology knowledge; ability to design experiments, troubleshoot, and document.
- US work authorization required (Lilly does not sponsor visas).
Additional Preferences
- PK/PD knowledge; spatial transcriptomics/RNAscope; CNS tissue/model experience; imaging/functional/effectiveness integration; CRO collaboration; FDA (2020) guidance/EMA reflection knowledge.
Other Information
- Fixed-term 1 year, extendable up to 4 years; daily on-site lab work in Boston, MA.
- Anticipated wage: $58,000–$123,200; may be eligible for bonus and comprehensive benefits.
- Postdoctoral Scientist, Drug Delivery and Connected Systems (DDCS): CNS gene therapy biodistribution and molecular bioanalysis to support translational advancement of viral and non-viral gene therapy for neurological/neurodegenerative diseases.
Key Responsibilities
- Lead design, development, optimization, and execution of biodistribution assays for AAVs, LNPs, siRNA distribution, transgene expression, and persistence across CNS and peripheral tissues.
- Apply vector biology/AAV serotype-specific biodistribution knowledge (e.g., AAV9, AAVrh10, PHP.eB).
- Use molecular/bioanalytical methods: PCR/qPCR/ddPCR, stem-loop PCR, vg/dg quantification; ELISA/immunoassays; LC–MS (as applicable); IHC and spatial tissue analyses; NGS for tracking/expression/integration.
- Ensure assays are fit-for-purpose (sensitive/reproducible) and aligned to translational objectives; conduct off-target analysis and DRG toxicology assay development.
- Independently design and troubleshoot CNS biodistribution studies using DoE/DOR; maintain rigorous documentation.
- Integrate biodistribution with PK/PD to guide dose/route/therapeutic index; link readouts to functional/anatomical/disease endpoints.
- Interface with external CROs and provide oversight for in vivo studies and molecular analyses.
- Analyze and visualize large datasets; communicate findings.
Basic Requirements
- PhD in Molecular Biology/Biochemistry/Pharmacology/Neuroscience/Bioengineering or related.
- In-depth AAV biodistribution and/or molecular bioanalytical assay development.
- Hands-on PCR/qPCR/ddPCR, ELISA, IHC, NGS, and/or related techniques.
- Solid CNS gene therapy/tissue biology knowledge; ability to design experiments, troubleshoot, and document.
- US work authorization required (Lilly does not sponsor visas).
Additional Preferences
- PK/PD knowledge; spatial transcriptomics/RNAscope; CNS tissue/model experience; imaging/functional/effectiveness integration; CRO collaboration; FDA (2020) guidance/EMA reflection knowledge.
Other Information
- Fixed-term 1 year, extendable up to 4 years; daily on-site lab work in Boston, MA.
- Anticipated wage: $58,000–$123,200; may be eligible for bonus and comprehensive benefits.