Postdoctoral Research Scientist, Proteomics
Neurocrine Biosciences
Full-time
Remote friendly (San Diego, CA)
United States
Clinical Research and Development
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Role Summary
Postdoctoral Research Scientist, Proteomics. Our biologics research team seeks a motivated, talented and collaborative scientist to apply mass spectrometry-based proteomics to pharmaceutical discovery, including applications in target identification, target engagement and pharmacodynamic biomarkers.
Responsibilities
- Develop robust proteome profiling and quantitation assays, perform in-house experiments on biological samples
- Work closely with the MS team to effectively utilize state-of-the-art instruments to implement proteomics methodologies that meet stakeholder needs
- Perform data analysis utilizing commercially available software and in-house developed platforms; optimize parameters to maximize value from acquired data
- Collaborate with project, pharmacology and translational biology teams as the subject matter expert; design and execute studies, analyze data and interpret results
- Maintain high quality standards for in-house studies through sample preparation, data acquisition and analysis; ensure quality and delivery of outsourced studies
- Present data at team meetings, lead discussions to guide decision making, prepare manuscripts for publication
Qualifications
- PhD in chemistry, biochemistry or biology
- Solid understanding of mass spectrometry and current proteomics techniques; hands-on experience on LC-MS instruments, immunoprecipitation and bottom-up sample preparation
- Experience on high-resolution TOF and/or Orbitrap mass analyzers is a plus
- Experience in methods including DIA, TMT and chemical labeling is desired
- Working knowledge of data processing software; experience in R or Python is desirable
- Experience to monitor and troubleshoot instrumentation, including mass spectrometers and associated LCs, to maintain uptime
- Strong understanding and experience in documenting all sample preparation, method development notes, author scientific reports/publications and protocols/SOPs
- Strong collaboration skills and the ability to work in / lead cross functional or multidisciplinary projects / teams
- Outstanding organizational skills and the ability to work independently
Education
- PhD in chemistry, biochemistry or biology (as listed above)