Postdoctoral Research Scientist, Proteomics

Role Summary

Postdoctoral Research Scientist, Proteomics focusing on mass spectrometry-based proteomics for pharmaceutical discovery, including applications in target identification, target engagement and pharmacodynamic biomarkers. The role involves working closely with in vitro and in vivo pharmacology, as well as project teams, to design and execute proteomics studies. The ideal candidate will bring strong scientific, technical and laboratory skills, along with excellent organizational and communication abilities to contribute in a fast-paced environment addressing novel therapeutic candidates.

Responsibilities

• Develop robust proteome profiling and quantitation assays, perform in-house experiments on biological samples
• Work closely with the MS team to effectively utilize state-of-the-art instruments to implement proteomics methodologies that meet stakeholder needs
• Perform data analysis utilizing commercially available software and in-house developed platforms; optimize parameters to maximize value from acquired data
• Collaborate with project, pharmacology and translational biology teams as the subject matter expert, design and execute studies, analyze data and interpret results
• Maintain high quality standards for in-house studies through sample preparation, data acquisition and analysis, ensure quality and delivery of outsourced studies
• Present data at team meetings, lead discussions to guide decision making, prepare manuscripts for publication

Qualifications

• PhD in chemistry, biochemistry or biology
• Solid understanding of mass spectrometry and current proteomics techniques, hands-on experience on LC-MS instruments, immunoprecipitation and bottom-up sample preparation is required
• Experience on high-resolution TOF and/or Orbitrap mass analyzers is a plus
• Experience in methods including DIA, TMT and chemical labeling is desired
• Working knowledge of data processing software, experience in R or Python is desirable
• Experience to monitor and troubleshoot instrumentation, including mass spectrometers, and associated LCs, to maintain uptime
• Strong understanding and experience in documenting all sample preparation, method development notes, author scientific reports/publications and protocols/SOPs
• Strong collaboration skills and the ability to work in / lead cross functional or multidisciplinary projects / teams, with a specific focus on how core technology is successfully applied to achieve the broader goals
• Outstanding organizational skills and the ability to work independently