Postdoctoral Research Scientist, Proteomics

Role Summary

Postdoctoral Research Scientist, Proteomics — apply mass spectrometry-based proteomics to pharmaceutical discovery, including target identification, target engagement and pharmacodynamic biomarkers. Collaborate with in-vitro and in-vivo pharmacology and project teams to design and execute proteomics studies.

Responsibilities

• Develop robust proteome profiling and quantitation assays; perform in-house experiments on biological samples
• Work closely with the MS team to utilize state-of-the-art instruments and implement proteomics methodologies to meet stakeholder needs
• Perform data analysis using commercially available software and in-house platforms; optimize parameters to maximize value from data
• Collaborate with project, pharmacology and translational biology teams as the subject matter expert; design and execute studies, analyze data and interpret results
• Maintain high quality standards for in-house studies through sample preparation, data acquisition and analysis; ensure quality and delivery of outsourced studies
• Present data at team meetings, lead discussions to guide decision making, prepare manuscripts for publication

Qualifications

• PhD in chemistry, biochemistry or biology
• Solid understanding of mass spectrometry and current proteomics techniques; hands-on experience with LC-MS instruments, immunoprecipitation and bottom-up sample preparation
• Experience on high-resolution TOF and/or Orbitrap mass analyzers is a plus
• Experience in methods including DIA, TMT and chemical labeling is desired
• Working knowledge of data processing software; experience in R or Python is desirable
• Experience to monitor and troubleshoot instrumentation, including mass spectrometers and LCs, to maintain uptime
• Strong documentation skills for sample preparation, method development notes, scientific reports/publications and protocols/SOPs
• Strong collaboration skills and ability to work in or lead cross-functional or multidisciplinary projects/teams
• Outstanding organizational skills and ability to work independently