Postdoctoral Fellow, Quantitative Systems Pharmacology
Pfizer
5 hours ago
Remote friendly (Cambridge, MA)
United States
Clinical Research and Development
Role Responsibilities
- Identify and integrate relevant data sources for model development, calibration, and validation, including published literature; internal preclinical and clinical study data; clinical biomarker data; and external real-world and multi-omics resources.
- Apply modeling and simulation approaches to predict clinical outcomes, identify novel indications, and provide novel mechanistic insight into incretin therapies.
- Communicate modeling results and strategic insights effectively to scientists from both quantitative and non-quantitative disciplines.
- Serve as primary author on scientific publications and present research findings at internal and external scientific meetings.
Basic Qualifications
- Ph.D. in Applied Mathematics, Mathematical Biology, Chemical Engineering, Biomedical Engineering, Physics, Pharmaceutical Sciences, Pharmacology, or related discipline with strong numerical components focusing on mathematical modeling and simulation.
- No more than 2 years of post-degree experience.
- Training or previous experience in building QSP or differential-equation-based models of biological or physiological pathways/systems.
- Understanding of theory, principles, and statistical aspects of mathematical modeling and simulation, including parameter estimation techniques.
- Knowledge of modeling/simulation software (MATLAB or Julia preferred) and AI agents.
- Willingness to make a minimum 2-year commitment.
- Provide two letters of recommendation prior to interview.
- Demonstrated scientific accomplishments (publications and/or presentations), including at least one first-author peer-reviewed journal publication.
Preferred Qualifications
- Enthusiasm for learning new areas of biology and building quantitative/computational skills.
- In-depth understanding of ordinary differential equations (ODEs) for complex biological pathway/system models.
- Self-directed; able to work independently.
- Team player with cross-functional collaboration across disciplines.
- Excellent communication and writing skills.
Physical/Mental Requirements
- Ability to perform mathematical calculations and complex data analysis.
Work Location Assignment
- Hybrid
Application Instructions
- Last day to apply: April 30th, 2026
Compensation/Benefits (if explicitly stated)
- Annual base salary range: $64,600.00 to $107,600.00; bonus target of 7.5% of base salary; eligible for Pfizer Global Performance Plan.
- Benefits include 401(k) with matching contributions, additional retirement savings contribution, paid vacation/holidays/personal days, paid caregiver/parental and medical leave, and health benefits (medical, prescription drug, dental, vision).
- Identify and integrate relevant data sources for model development, calibration, and validation, including published literature; internal preclinical and clinical study data; clinical biomarker data; and external real-world and multi-omics resources.
- Apply modeling and simulation approaches to predict clinical outcomes, identify novel indications, and provide novel mechanistic insight into incretin therapies.
- Communicate modeling results and strategic insights effectively to scientists from both quantitative and non-quantitative disciplines.
- Serve as primary author on scientific publications and present research findings at internal and external scientific meetings.
Basic Qualifications
- Ph.D. in Applied Mathematics, Mathematical Biology, Chemical Engineering, Biomedical Engineering, Physics, Pharmaceutical Sciences, Pharmacology, or related discipline with strong numerical components focusing on mathematical modeling and simulation.
- No more than 2 years of post-degree experience.
- Training or previous experience in building QSP or differential-equation-based models of biological or physiological pathways/systems.
- Understanding of theory, principles, and statistical aspects of mathematical modeling and simulation, including parameter estimation techniques.
- Knowledge of modeling/simulation software (MATLAB or Julia preferred) and AI agents.
- Willingness to make a minimum 2-year commitment.
- Provide two letters of recommendation prior to interview.
- Demonstrated scientific accomplishments (publications and/or presentations), including at least one first-author peer-reviewed journal publication.
Preferred Qualifications
- Enthusiasm for learning new areas of biology and building quantitative/computational skills.
- In-depth understanding of ordinary differential equations (ODEs) for complex biological pathway/system models.
- Self-directed; able to work independently.
- Team player with cross-functional collaboration across disciplines.
- Excellent communication and writing skills.
Physical/Mental Requirements
- Ability to perform mathematical calculations and complex data analysis.
Work Location Assignment
- Hybrid
Application Instructions
- Last day to apply: April 30th, 2026
Compensation/Benefits (if explicitly stated)
- Annual base salary range: $64,600.00 to $107,600.00; bonus target of 7.5% of base salary; eligible for Pfizer Global Performance Plan.
- Benefits include 401(k) with matching contributions, additional retirement savings contribution, paid vacation/holidays/personal days, paid caregiver/parental and medical leave, and health benefits (medical, prescription drug, dental, vision).