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Postdoctoral Fellow, Immunology

Ionis Pharmaceuticals, Inc.
Full-time
On-site
Carlsbad, CA
$65,000 - $87,000 USD yearly
Clinical Research and Development

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Role Summary

POSTDOCTORAL FELLOW - IMMUNOLOGY

We are seeking a highly motivated and highly productive Postdoctoral Fellow to contribute to advancing targeted RNA-therapeutics delivery to immune cells. This role offers a unique opportunity to gain deep research experience in a fast-paced industry environment while making a meaningful contribution to the development of next-generation RNA medicines. The successful candidate will explore and validate receptor-based delivery strategies on immune cell subsets to enable efficient uptake of diverse RNA-targeted modalities. The project integrates computational profiling, ligand screening, in vitro and in vivo validation strategies to overcome delivery challenges and establish compelling proof-of-concept data. This position provides a rare chance to shape innovative therapeutic approaches, generate patentable and publishable discoveries, and work at the intersection of cutting-edge science and real-world drug development.

Responsibilities

  • Identify and prioritize cell-surface receptors relevant to immune-cell biology, applying scientific creativity and critical thinking to advance delivery strategies.
  • Validate receptor expression and function using advanced analytical approaches, including flow cytometry, single-cell profiling, and RNA-seq.
  • Design and execute in vitro and in vivo studies to evaluate target knockdown, delivery efficiency, and cell-type specificity, exercising sound judgment within established procedures.
  • Analyze and interpret complex datasets to guide decision-making, review key technical factors, and shape project strategy.
  • Document experimental results and communicate clear, concise findings through regular internal presentations, writing manuscripts for scientific publications, and contributions to posters.
  • Collaborate effectively with cross-functional teams and external partners, building alignment around technical decisions and contributing to collective problem-solving.
  • Contribute to innovation and intellectual property development through rigorous experimentation and documentation.
  • Demonstrate professionalism and uphold the companyβ€šΓ„Γ΄s culture, core principles, and collaborative working norms.

Qualifications

  • Ph.D. in Immunology, Molecular Biology, Cell Biology, or related fields with 0-3 years of postgraduate training
  • Familiarity with flow cytometry, including panel design and data analysis
  • Experience with cell culture techniques, including primary immune cell isolation and maintenance
  • In vivo study experience or willingness to learn
  • Experience with molecular biology methods (e.g., RNA analysis, qPCR, siRNA/ASO delivery)
  • Strong background in immunology and lymphocyte biology is a plus
  • Ability to analyze large datasets (e.g., scRNA-seq, transcriptomics) and interpret receptor expression profiles is a plus
  • Excellent problem-solving skills and ability to design experiments independently
  • Strong written and verbal communication skills for publication and presentation
  • Full-time onsite at Carlsbad, CA

Skills

  • Experiment design and data interpretation
  • Cell biology techniques and receptor biology
  • In vivo and in vitro study execution
  • Scientific communication and collaboration
  • Intellectual property development and documentation

Education

  • Ph.D. in Immunology, Molecular Biology, Cell Biology, or related field

Additional Requirements

  • Onsite work requirement at Carlsbad, CA
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