Post Doctoral Scientist - Large Molecule Discovery

Role Summary

Post Doctoral Scientist - Large Molecule Discovery at Lilly Oncology, focusing on developing ADC linker-technologies and bioconjugation platforms. The role involves joining a multi-disciplinary team to support linker-payload design, bioconjugation, and downstream biochemical assays to enhance ADC properties.

Responsibilities

• Work within a scientific team, conceptualizing and executing new site-specific bioconjugation and linker technologies for modalities such as ADCs, ARCs, DACs, etc.
• Implement state-of-the-art bioconjugation technologies (cysteine, lysine, site-specific and other) and utilize novel chemistries to generate bioconjugates.
• Develop purification strategies (up to 200 mg) with affinity, ion-exchange, hydrophobic interaction, size exclusion, and tangential flow filtration.
• Characterize ADCs using UV-Vis, SEC, HIC, RP, IEX, cIEF, and LC-MS.
• Maintain thorough documentation of experimental procedures in electronic notebook or database, writing of reports and technical documents.
• Maintain scientific and technical expertise through familiarity with scientific literature and attending conferences.
• Engage with multidisciplinary project teams to design, execute, and interpret experiments.
• Demonstrated record of scientific accomplishments and publications.
• Present periodic updates and reports to management team.
• Maintain a safe, pleasant, and efficient working environment.

Qualifications

• PhD in chemistry, biochemistry, or other related scientific discipline

Additional Requirements

• Strong hands-on experience producing and characterizing antibody and protein drug conjugates using HIC, SEC, LC-MS, IEX, and RP-HPLC.
• Experience with protein purification systems, with hands-on proficiency working with AKTA FPLCs.
• Highly collaborative and able to effectively engage small-molecule research project teams to make rapid progress.
• Ability to work well with other professionals within and across functions/teams.
• Ability to multi-task and shift priorities rapidly to meet tight deadlines.
• Excellent written and verbal communicator.
• Detail oriented and well organized.
• Enthusiastic, self-motivated, and keen to improve processes.
• Self-motivation and continual learner mindset.
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, and staff at all levels.