Physician Scientist – Obesity and Liver Disease Human Genetics

Role Summary

Physician Scientist to join the Cardiometabolic Therapeutic Area Genetics (TAG) team at Regeneron Genetics Center (RGC) to accelerate therapeutic development for genetically-validated targets in obesity and metabolic disease through human genetics and epidemiological insights.

Responsibilities

• Accelerate therapeutic development for genetically-validated targets via the generation of new human genetics and epidemiological insights.
• Generate key research questions and design and execute studies and analyses; interpret results and summarize insights for diverse audiences (documents, presentations, patent applications, publications, etc.).
• Leverage RGC and Regeneron datasets, external resources, and literature to address key questions and summarize results with appropriate weight to evidence strength.
• Support target nominations and validation using RGC‚Äôs human genetics capabilities and Regeneron platforms.
• Partner with Clinical Development to evaluate clinical stage programs and opportunities for human genetics studies to aid in indication selection or safety considerations.
• Participate in the intellectual life of the Cardiometabolic TAG, RGC, and Regeneron to build an inclusive culture and develop talent.
• Represent the Therapeutic Area Genetics team in cross-functional initiatives within RGC and Regeneron.

Qualifications

• Demonstrated ability to design and lead human genetics and epidemiological studies delivering medically-relevant findings in a team-based environment.
• Ability to define relevant phenotypes for genetic association studies; familiarity with clinical genetics concepts and genetic models of disease.
• Strong computational and quantitative skills; experience with large-scale datasets (e.g., UK Biobank, All of Us, MVP, Biobank Japan) and proficiency with R or similar software; familiarity with HPC environments.
• Experience leading complex human genetics research; knowledge of GWAS, exome/genome sequencing in cohorts, case-control or family-based studies; ability to integrate diverse data resources.
• Familiarity with applying genetics to obtain medically-actionable insights (polygenic risk scores, quantitative traits, Mendelian randomization).
• Understanding of drug development and clinical trial design; experience as an investigator in randomized controlled trials is a plus; cardio-metabolic disease experience is optional but advantageous.

Education

• MD with strong background in human genetics and genetic epidemiology; MD/PhD with translational human genetics training is preferred.