Pharmacology Research Scientist
Vertex Pharmaceuticals
2 months ago
On-site
San Diego, CA
Clinical Research and Development
Key Duties And Responsibilities
- Develop, optimize, and implement primary tissue assays to support drug discovery and development programs.
- Design and execute experiments utilizing ex vivo organ perfusion and nervous system models to evaluate drug efficacy, distribution, safety, and mechanism of action.
- Conduct in vitro and in vivo pharmacology studies to complement ex vivo findings and provide a comprehensive understanding of drug candidates.
- Automate data collection and analysis processes to improve efficiency and accuracy in experimental workflows.
- Collaborate with cross-functional teams (medicinal chemistry, biology, toxicology, clinical development) to advance projects from discovery to clinical development.
- Analyze, interpret, and present experimental data to project teams and senior leadership.
- Author and review study reports, regulatory documents, and scientific publications.
- Stay current with advancements in pharmacology and ex vivo systems to incorporate innovative approaches.
Knowledge And Skills
- Proficiency in pharmacology techniques, including cell-based assays, physiology, animal handling, dosing, and tissue dissection/collection.
- Strong analytical and problem-solving skills; ability to automate data collection/analysis and interpret complex datasets.
- Proficiency with data analysis software/tools (e.g., GraphPad Prism, Spotfire, MATLAB, Python).
- Excellent communication and presentation skills; collaborative team skills.
Education And Experience
- Ph.D. in Pharmacology, Biology, or related field with 0–3 years relevant experience; or Master’s with 3+ years; or Bachelor’s with 6 years in a pharmaceutical/biotechnology setting.
- Hands-on experience developing and applying primary tissue assays, including ex vivo organ perfusion and nervous system models.
Pay/Compensation
- Pay range: $110,900 - $166,300
- Eligible for an annual bonus and annual equity awards.
Flex (Work Location)
- On-site designated role; five days per week on-site with ad hoc flexibility.
- Develop, optimize, and implement primary tissue assays to support drug discovery and development programs.
- Design and execute experiments utilizing ex vivo organ perfusion and nervous system models to evaluate drug efficacy, distribution, safety, and mechanism of action.
- Conduct in vitro and in vivo pharmacology studies to complement ex vivo findings and provide a comprehensive understanding of drug candidates.
- Automate data collection and analysis processes to improve efficiency and accuracy in experimental workflows.
- Collaborate with cross-functional teams (medicinal chemistry, biology, toxicology, clinical development) to advance projects from discovery to clinical development.
- Analyze, interpret, and present experimental data to project teams and senior leadership.
- Author and review study reports, regulatory documents, and scientific publications.
- Stay current with advancements in pharmacology and ex vivo systems to incorporate innovative approaches.
Knowledge And Skills
- Proficiency in pharmacology techniques, including cell-based assays, physiology, animal handling, dosing, and tissue dissection/collection.
- Strong analytical and problem-solving skills; ability to automate data collection/analysis and interpret complex datasets.
- Proficiency with data analysis software/tools (e.g., GraphPad Prism, Spotfire, MATLAB, Python).
- Excellent communication and presentation skills; collaborative team skills.
Education And Experience
- Ph.D. in Pharmacology, Biology, or related field with 0–3 years relevant experience; or Master’s with 3+ years; or Bachelor’s with 6 years in a pharmaceutical/biotechnology setting.
- Hands-on experience developing and applying primary tissue assays, including ex vivo organ perfusion and nervous system models.
Pay/Compensation
- Pay range: $110,900 - $166,300
- Eligible for an annual bonus and annual equity awards.
Flex (Work Location)
- On-site designated role; five days per week on-site with ad hoc flexibility.