Pharmacology Research Scientist

Role Summary

We are seeking a talented, self-motivated and collaborative in-vivo pharmacologist to join the integrated pharmacology team supporting late-stage drug discovery. The ideal candidate will have a strong foundation in pharmacology, work with a high degree of independence and be adept at conceptually designing, executing and interpreting in vivo/ex vivo experiments to establish therapeutic proof-of-concept across diverse disease areas.

Responsibilities

• Designs and conducts elaborate, conceptually connected, multi-component in vivo/ex vivo experiments to demonstrate proof-of-concept in preclinical disease models including pharmacokinetic, pharmacodynamic and efficacy relationships.
• Perform advanced and/or complex experimental assay development and troubleshooting.
• Collates and interprets complex data systematically and synthesizes results into a cohesive body of conclusions or recommendations to guide Project decisions and new research activities.
• Exercises solid judgment to prioritize studies, considering feasibility and Project impact.
• Scours relevant scientific literature and routinely incorporates new insights into research activities.
• Identifies, prioritizes and introduces relevant emerging technologies in their field of expertise to advance the existing technology platforms and create/maintain a competitive advantage.
• Explores the feasibility of applying new scientific principles/concepts or implements and validates novel experimental approaches and technologies to achieve project goals.
• Contributes significantly to patent and/or publication preparation.
• Independently prepares study presentations and presents experimental conclusions at internal Group/Department or Project Team research meetings.
• Performs other duties as assigned.

Skills

• Designs and executes complex, well controlled, challenging experiments that measure the action of compounds on in vivo/ex vivo disease biology assays.
• Maintains a broad working knowledge of fundamental pharmacology principles.
• Demonstrates astute understanding of his/her own discipline and the relevant literature.
• Maintains a high level of knowledge related to current developments in the scientific Project field.
• Displays proven productivity and experimental creativity, and effective dissemination of ideas.
• Demonstrates effective, self-sufficient communication skills, especially in peer-directed presentations.
• Demonstrates awareness of other Project-related disciplines and an understanding of general concepts and some experimental detail within those areas.
• Must be proficient in rodent handling, dosing (IV, PO, IP, SC), blood collection (tail nick, submandibular, cardiac puncture) and tissue harvesting.
• Demonstrate experience developing, executing and troubleshooting assays across a wide array of in vivo and molecular techniques (i.e. ELISA, qPCR, Western and flow cytometry).
• Ability to rapidly learn and master new techniques and technologies.
• Essential qualities include: integrity, flexibility, adaptability, organization and multi-tasking skills, excellent record keeping and the ability to function both independently and effectively as part of an interactive and cross-functional team.

Education

• Bachelor's degree in pharmacology or related biological sciences
• Typically requires a PhD and 0-3 years of experience or,
• Typically requires a Masters degree and 3 years of experience or,
• Typically requires a Bachelors degree and 6 years of experience