Pathology Senior Principal Research Scientist
Vertex Pharmaceuticals
June 27, 2026
On-site
Boston, MA
Clinical Research and Development
Key Responsibilities:
- Provide scientific leadership in the design, conduct, and interpretation of pathology endpoints for animal model development, target identification/validation, and in vivo pharmacology and nonclinical biomarker development studies, using molecular diagnostic and digital imaging technologies.
- Prepare photographic/video images of pathology specimens for group/project presentations, reports, publications, and presentations.
- Conduct anatomic pathology evaluation of investigative pathology and regulatory toxicity studies from lead identification/optimization through registration and post-marketing approval.
- Lead discovery, translational research, and regulatory nonclinical safety profiling on cross-functional teams with preclinical safety and biomarker scientists.
- Participate in regulatory submission document preparation, poster presentations, scientific publications, and address queries from global health authorities.
- Potential additional role: Preclinical safety representative on discovery and/or development project teams.
Minimal Requirements:
- DVM (or equivalent) and ACVP/ECVP board certification in veterinary anatomic pathology.
- PhD in a relevant scientific discipline (strongly preferred).
- 1–3 years’ experience in discovery and/or toxicologic pathology (pharma/biotech) or gross/histologic assessment of laboratory animals.
- Preferred: experience using imaging technologies and molecular diagnostic pathology techniques.
- Demonstrated excellence in oral/written communication, interpersonal skills, critical thinking, issue resolution, and mentoring non-DVM scientists/lab associates.
- Ability to contribute to timely, consensus-based decision-making.
- Plus: experience with genetic/cell therapies; IHC/ISH, multiplex imaging, digital pathology tools, tissue-based biomarker interpretation; drive adoption of AI-powered histopathology solutions.
Pay Range: $180,000 - $270,000
Disclosure/Compensation: Eligible for annual bonus and annual equity awards.
- Provide scientific leadership in the design, conduct, and interpretation of pathology endpoints for animal model development, target identification/validation, and in vivo pharmacology and nonclinical biomarker development studies, using molecular diagnostic and digital imaging technologies.
- Prepare photographic/video images of pathology specimens for group/project presentations, reports, publications, and presentations.
- Conduct anatomic pathology evaluation of investigative pathology and regulatory toxicity studies from lead identification/optimization through registration and post-marketing approval.
- Lead discovery, translational research, and regulatory nonclinical safety profiling on cross-functional teams with preclinical safety and biomarker scientists.
- Participate in regulatory submission document preparation, poster presentations, scientific publications, and address queries from global health authorities.
- Potential additional role: Preclinical safety representative on discovery and/or development project teams.
Minimal Requirements:
- DVM (or equivalent) and ACVP/ECVP board certification in veterinary anatomic pathology.
- PhD in a relevant scientific discipline (strongly preferred).
- 1–3 years’ experience in discovery and/or toxicologic pathology (pharma/biotech) or gross/histologic assessment of laboratory animals.
- Preferred: experience using imaging technologies and molecular diagnostic pathology techniques.
- Demonstrated excellence in oral/written communication, interpersonal skills, critical thinking, issue resolution, and mentoring non-DVM scientists/lab associates.
- Ability to contribute to timely, consensus-based decision-making.
- Plus: experience with genetic/cell therapies; IHC/ISH, multiplex imaging, digital pathology tools, tissue-based biomarker interpretation; drive adoption of AI-powered histopathology solutions.
Pay Range: $180,000 - $270,000
Disclosure/Compensation: Eligible for annual bonus and annual equity awards.