Optics / Microscopy Principal Scientist

Role: Principal Scientist specializing in optical design, microscopy, and functional imaging to develop advanced optical instruments for drug discovery at Vertex's San Diego site. Responsibilities: collaborate with multidisciplinary teams to identify project needs, design and prototype optical tools, perform proof-of-concept experiments, optimize biological assays, and work with engineers to develop robust instruments for high-throughput automated platforms. Requirements: Ph.D. in Physics, Bioengineering, or related field; 8+ years of experience in optical techniques, biological imaging modalities (e.g., confocal, super-resolution, two-photon microscopy), with hands-on experience in biological research applications. Skills: strong knowledge of optical design principles, engineering specifications, automation, and high-throughput screening; proficiency in programming for data analysis and instrument control; excellent communication and mentorship abilities. High-Value: focus on instrumentation integrated into drug discovery pipelines, functional cellular measurements (voltage, calcium imaging), biologics or small molecule contexts, on-site role with flexible work arrangements; salary range $144,400–$216,600, with potential bonuses and equity.