Operational Excellence Leader: NASD

Role: Operational Excellence Lead in biopharma manufacturing, focused on building and sustaining production systems for therapeutic oligonucleotides at GMP facilities. Responsibilities include deploying structured process improvement across the full Make value stream, developing daily management systems, leading kaizen initiatives, and translating corporate objectives into floor-level actions. The role emphasizes real-time data analysis, root-cause problem-solving, and integrating digital tools to enhance throughput, yield, and cycle time. It involves supporting tech transfer and new product introduction to enable faster, scalable, and deviation-free onboarding of new molecules. The position requires coaching site teams in Lean methodologies, standard work, and governance routines to embed durable operational improvements. Collaboration spans site leadership, quality, and manufacturing teams, with a focus on transforming operational performance into measurable business results like capacity, on-time delivery, and cost reduction. Qualifications include a Bachelor’s or Master’s in life sciences, chemical, or biochemical engineering, with over 10 years’ GMP manufacturing experience, including 8+ years of hands-on Lean deployment and process performance accountability. Deep expertise in chemical or pharmaceutical synthesis, GMP, and structured problem-solving is essential. Preferred qualifications include experience in biologics or pharma tech transfer, process validation, and Lean or Six Sigma certifications. The role is based in the US, with significant travel (~50%) to facilities in Colorado, and offers remote work options. It is a senior-level position within a global enterprise function, with an emphasis on cross-site deployment and leadership.