Modeling & Simulations Associate Director
Vertex Pharmaceuticals
August 08, 2026
Remote friendly (Boston, MA)
United States
Clinical Research and Development
General Summary:
The Modeling & Simulations Associate Director will be responsible for developing and executing M&S strategies and activities in cross-functional drug development project teams in collaboration with colleagues in Clinical Pharmacology, Biostatistics, Research, and other R&D partners. The role determines, plans, and executes technically challenging analyses using state-of-the-art Modeling & Simulation methodologies to contribute to critical decision making.
Key Duties And Responsibilities:
- Serve as Modeling & Simulations (M&S) lead in one or more cross-functional drug development teams; develop and execute integrated M&S plans and analyses.
- Use Modeling & Simulation to support critical decision making (e.g., study design, dose selection, probability of success estimation).
- Independently perform mechanism-based PKPD and population PK/PKPD analyses, clinical trial simulations, and other model-based analyses.
- Improve M&S capability by supporting training, evaluating, and incorporating new M&S tools.
Knowledge And Skills:
- Specialized understanding of biology, pharmacokinetic and quantitative pharmacology (PKPD) principles.
- Hands-on skills: population PK/PKPD modeling, mechanistic PKPD modeling, clinical trial simulations, disease progression modeling.
- Proficiency with NonMem, PsN, R, Phoenix, and similar tools.
- Strong leadership, collaboration, and influencing skills; excellent verbal and written communication.
- In-depth experience in clinical development teams and integrating PK/PD modeling of complex biological systems.
Education And Experience:
- Master’s or PhD (preferred: Pharmaceutical sciences, Pharmacometrics, mathematics, statistics, or related quantitative discipline with Pharmacometrics/PKPD focus).
- Typically: PhD + 6 years OR Master’s + 10 years applying pharmacometric and modeling methodologies in drug research & development (industry, academia, or regulatory agencies).
The Modeling & Simulations Associate Director will be responsible for developing and executing M&S strategies and activities in cross-functional drug development project teams in collaboration with colleagues in Clinical Pharmacology, Biostatistics, Research, and other R&D partners. The role determines, plans, and executes technically challenging analyses using state-of-the-art Modeling & Simulation methodologies to contribute to critical decision making.
Key Duties And Responsibilities:
- Serve as Modeling & Simulations (M&S) lead in one or more cross-functional drug development teams; develop and execute integrated M&S plans and analyses.
- Use Modeling & Simulation to support critical decision making (e.g., study design, dose selection, probability of success estimation).
- Independently perform mechanism-based PKPD and population PK/PKPD analyses, clinical trial simulations, and other model-based analyses.
- Improve M&S capability by supporting training, evaluating, and incorporating new M&S tools.
Knowledge And Skills:
- Specialized understanding of biology, pharmacokinetic and quantitative pharmacology (PKPD) principles.
- Hands-on skills: population PK/PKPD modeling, mechanistic PKPD modeling, clinical trial simulations, disease progression modeling.
- Proficiency with NonMem, PsN, R, Phoenix, and similar tools.
- Strong leadership, collaboration, and influencing skills; excellent verbal and written communication.
- In-depth experience in clinical development teams and integrating PK/PD modeling of complex biological systems.
Education And Experience:
- Master’s or PhD (preferred: Pharmaceutical sciences, Pharmacometrics, mathematics, statistics, or related quantitative discipline with Pharmacometrics/PKPD focus).
- Typically: PhD + 6 years OR Master’s + 10 years applying pharmacometric and modeling methodologies in drug research & development (industry, academia, or regulatory agencies).