Mixed Modality (Peptide Upstream) Scientist - Process Translation and Execution
Eli Lilly and Company
August 07, 2026
On-site
Lebanon, IN
Operations
Responsibilities:
- Synthetically evaluate and facilitate transfer of peptide upstream manufacturing processes from development labs to pilot plant operations (kilo-scale and isolator environments) for early-phase cGMP API (grams to kilograms).
- Perform synthetic peptide chemistry; assess synthetic routes.
- Familiar with peptide upstream procedures such as SPPS and Cleavage & Precipitation.
- Evaluate safety of incoming procedures with safety and process engineering.
- Order and stage chemicals; obtain reference materials; set up analytical methods.
- Reprocess and analyze analytical data to make fact-based decisions.
- Summarize and present chemistry and challenges; execute plant readiness familiarizations for key steps (SPPS, Cleavage & Precipitation).
- Perform raw material use-tests; document Definitive Lab Trials to confirm plant readiness.
- Maintain detailed lab notebooks for technical packages/transfers and replication.
- Author/review technical documents: tech transfer plans, SOPs, batch records, campaign summary and deviation reports.
- Apply scientific knowledge to improve processes; implement new technologies/procedures.
- Support troubleshooting/investigations, process deviations, quality events, non-conformances; perform RCA and develop CAPAs.
Basic Requirements:
- B.S. or M.S. in chemistry, chemical engineering, or related field.
- 3+ years’ experience in peptide chemistry and/or manufacturing environments involving synthetic peptide API/drug substance (SPPS preferred).
- Authorized to work in the U.S. full-time; Lilly will not sponsor work authorization/visas.
Additional Preferences:
- Working knowledge of peptide chemistry/mechanisms for optimization.
- Experience scaling synthetic chemistry; solid process chemistry concepts a plus.
- Proficiency in peptide crude synthesis via SPPS and cleavage/deprotection.
- Comfortable with larger glass equipment; strong attention to detail; highly motivated.
- Experience creating batch records and conducting scale-up experiments.
- Prioritize multiple activities; manage ambiguity.
- Analytical techniques: HPLC/UPLC, LC-MS, GC, NMR, etc.; mass balance/quantification.
- Drive projects, accept change; excellent written/verbal communication.
- Familiarity with peptide downstream purification (TFF, lyophilization), precipitation, safe handling of solids/dry end.
- Problem-solving with data analysis and RCA.
- Cross-functional collaboration with engineering/analytical/safety/quality.
Application Instructions:
- (Work authorization notice) Applicants must be authorized to work in the U.S. full-time; no visa sponsorship.
- Synthetically evaluate and facilitate transfer of peptide upstream manufacturing processes from development labs to pilot plant operations (kilo-scale and isolator environments) for early-phase cGMP API (grams to kilograms).
- Perform synthetic peptide chemistry; assess synthetic routes.
- Familiar with peptide upstream procedures such as SPPS and Cleavage & Precipitation.
- Evaluate safety of incoming procedures with safety and process engineering.
- Order and stage chemicals; obtain reference materials; set up analytical methods.
- Reprocess and analyze analytical data to make fact-based decisions.
- Summarize and present chemistry and challenges; execute plant readiness familiarizations for key steps (SPPS, Cleavage & Precipitation).
- Perform raw material use-tests; document Definitive Lab Trials to confirm plant readiness.
- Maintain detailed lab notebooks for technical packages/transfers and replication.
- Author/review technical documents: tech transfer plans, SOPs, batch records, campaign summary and deviation reports.
- Apply scientific knowledge to improve processes; implement new technologies/procedures.
- Support troubleshooting/investigations, process deviations, quality events, non-conformances; perform RCA and develop CAPAs.
Basic Requirements:
- B.S. or M.S. in chemistry, chemical engineering, or related field.
- 3+ years’ experience in peptide chemistry and/or manufacturing environments involving synthetic peptide API/drug substance (SPPS preferred).
- Authorized to work in the U.S. full-time; Lilly will not sponsor work authorization/visas.
Additional Preferences:
- Working knowledge of peptide chemistry/mechanisms for optimization.
- Experience scaling synthetic chemistry; solid process chemistry concepts a plus.
- Proficiency in peptide crude synthesis via SPPS and cleavage/deprotection.
- Comfortable with larger glass equipment; strong attention to detail; highly motivated.
- Experience creating batch records and conducting scale-up experiments.
- Prioritize multiple activities; manage ambiguity.
- Analytical techniques: HPLC/UPLC, LC-MS, GC, NMR, etc.; mass balance/quantification.
- Drive projects, accept change; excellent written/verbal communication.
- Familiarity with peptide downstream purification (TFF, lyophilization), precipitation, safe handling of solids/dry end.
- Problem-solving with data analysis and RCA.
- Cross-functional collaboration with engineering/analytical/safety/quality.
Application Instructions:
- (Work authorization notice) Applicants must be authorized to work in the U.S. full-time; no visa sponsorship.