Medical Director, Oncology Clinical Development
Denali Therapeutics
June 28, 2026
Remote friendly (South San Francisco, CA)
United States
Clinical Research and Development
Key Accountabilities / Core Job Responsibilities:
- Contribute to the development and execution of clinical development strategies for oncology programs leveraging the Transport Vehicle platform.
- Provide clinical and scientific leadership across study design, execution, analysis, interpretation, and reporting of early- and late-phase oncology trials.
- Lead development of clinical protocols, amendments, investigator brochures, and clinical study reports.
- Provide medical monitoring support, including evaluation of safety, pharmacology, and efficacy.
- Partner cross-functionally with Translational Sciences, Clinical Pharmacology, Regulatory Affairs, and other functions to integrate biomarker and translational strategies.
- Support clinical-regulatory strategy and interactions with health authorities.
- Engage with external experts, investigators, and advisory boards in oncology and neuro-oncology.
- Contribute to biomarker development, patient selection strategies, and innovative trial designs.
- Prepare scientific communications, including presentations and publications.
- Contribute to lifecycle planning and evaluation of new oncology development opportunities.
- Lead one or more oncology clinical programs with accountability for program-level strategy, execution, and delivery.
- Independently drive clinical trial activities while contributing to broader strategic discussions.
- Apply clinical expertise in hematology/oncology or neuro-oncology to inform study design, endpoints, and patient selection.
Qualifications/Skills:
- MD or MD/PhD with board certification or eligibility in Hematology/Oncology (adult or pediatric) or Neuro-Oncology.
- ~3+ years of clinical development experience in industry or equivalent clinical/academic research experience (e.g., fellowship/post-fellowship research, junior faculty).
- Strong scientific background in cancer biology, translational sciences, or clinical trial design.
- Demonstrated ability to lead program-level activities and collaborate effectively.
- Contribute to the development and execution of clinical development strategies for oncology programs leveraging the Transport Vehicle platform.
- Provide clinical and scientific leadership across study design, execution, analysis, interpretation, and reporting of early- and late-phase oncology trials.
- Lead development of clinical protocols, amendments, investigator brochures, and clinical study reports.
- Provide medical monitoring support, including evaluation of safety, pharmacology, and efficacy.
- Partner cross-functionally with Translational Sciences, Clinical Pharmacology, Regulatory Affairs, and other functions to integrate biomarker and translational strategies.
- Support clinical-regulatory strategy and interactions with health authorities.
- Engage with external experts, investigators, and advisory boards in oncology and neuro-oncology.
- Contribute to biomarker development, patient selection strategies, and innovative trial designs.
- Prepare scientific communications, including presentations and publications.
- Contribute to lifecycle planning and evaluation of new oncology development opportunities.
- Lead one or more oncology clinical programs with accountability for program-level strategy, execution, and delivery.
- Independently drive clinical trial activities while contributing to broader strategic discussions.
- Apply clinical expertise in hematology/oncology or neuro-oncology to inform study design, endpoints, and patient selection.
Qualifications/Skills:
- MD or MD/PhD with board certification or eligibility in Hematology/Oncology (adult or pediatric) or Neuro-Oncology.
- ~3+ years of clinical development experience in industry or equivalent clinical/academic research experience (e.g., fellowship/post-fellowship research, junior faculty).
- Strong scientific background in cancer biology, translational sciences, or clinical trial design.
- Demonstrated ability to lead program-level activities and collaborate effectively.