Medical Director, Experimental Medicine

Responsibilities:
- Inform preclinical experimental plans for in vitro and in vivo pharmacology and toxicology packages.
- Develop biomarker strategy for preclinical assets and guide experiment execution to support downstream clinical use prior to clinic entry.
- Formulate clinical development plans with emphasis on demonstrating proof of mechanism in first-in-human/first-in-patient studies and proof of concept in-clinic.
- Serve as clinical development team lead for research-phase assets through Phase 1 completion.
- Lead clinical contributions to pre-IND and IND submissions (and other stage-appropriate regulatory submissions).
- Lead clinical contributions to Phase 1 study protocols and trial-related documents.
- Design and execute natural history studies to (1) deepen understanding of targeted patient populations and (2) develop endpoints enabling efficient POC and/or approval.
- Serve as clinical expert for new project identification (internal programs and business development).
- Represent Experimental Medicine at scientific advisory and academic meetings.
- Serve as Medical Monitor on BioMarin clinical trials.

Qualifications:
- MD required; MD/PhD preferred.
- Ability to work collaboratively in a matrixed, fast-paced environment.
- Interest and curiosity in development challenges.
- Effective and impactful in cross-functional team structures.
- Excellent communication skills with desire to build strong internal and external collaborations.