Manager, Screening & Compound Management
PTC Therapeutics, Inc.Want to see how your resume matches up to this job? A free trial of our JobsAI will help! With over 2,000 biopharma executives loving it, we think you will too! Try it now — JobsAI.
Role Summary
The Manager, Screening and Compound Management is integral to optimizing high-throughput screening robotic platforms and compound operations, directly supporting drug discovery initiatives. This role ensures the execution of high-quality biochemical and cell-based assays, overseeing vital processes such as compound handling, storage, and screening. By safeguarding the integrity of compound libraries and streamlining workflows, the manager accelerates research timelines and delivers essential data for early-stage drug development. Leading a multidisciplinary team, the manager fosters a collaborative environment that champions innovation and continuous improvement through the adoption of advanced technologies like automated liquid handling systems and sophisticated data analytics tools.
Responsibilities
- Lead the strategic planning and execution of high-throughput screening campaigns, ensuring that all activities align with organizational goals and project timelines.
- Collaborating with cross-functional teams to design robust screening workflows, optimize assay conditions, and implement cutting-edge technologies to enhance data quality and throughput.
- The ability to anticipate challenges, troubleshoot technical issues, and adapt strategies will be critical in maintaining the efficiency and reliability of screening operations.
- Provide detailed reports and analyses of screening outcomes, ensuring that findings are effectively communicated to stakeholders and integrated into broader research initiatives.
- Overseeing the management of the compound library, a cornerstone of the organization’s research and development efforts.
- Implementing advanced inventory management systems and establishing rigorous quality control protocols.
- Work closely with medicinal chemistry teams to expand the library with diverse and high-value compounds while maintaining compliance with regulatory and safety standards.
- Oversee the development of strategies to optimize compound storage conditions and ensure long-term stability, safeguarding the organization’s investment in its chemical assets.
- Interact with a multidisciplinary team of scientists and technicians, providing mentorship, performance feedback, and opportunities for professional growth.
- Driving continuous improvement initiatives to enhance the efficiency and impact of screening and compound management processes.
- Establishing key performance indicators (KPIs) to measure the effectiveness of processes and identify areas for optimization, ensuring that all initiatives are aligned with the organization’s strategic objectives.
Qualifications
- Bachelor’s degree in chemistry, biology, biochemistry, or a related field with a minimum of 8 years of experience in compound management, high-throughput screening, or a related area within the pharmaceutical or biotechnology industry
- Master’s degree or Ph.D in a scientific discipline is preferred.
- Hands-on experience in managing compound libraries, designing screening workflows, and utilizing automation technologies will be highly advantageous.
- Competency in at least one programming language (e.g., C++, Visual Basic, Python, JavaScript, Java).
- Proficiency in laboratory automation systems, liquid handling platforms, and data management tools.
- Familiarity with LIMS (e.g., Scigilian, Dotmatics), automation systems (Cellario and Strata), and cheminformatics platforms.
- Solid understanding of assay development and optimization, with the ability to troubleshoot technical challenges in a dynamic research environment.
- Familiarity with traditional HTS assay detection methods including qPCR, Mesoscale, luminescence, FP, TR-FRET.
- Strategic mindset and a commitment to driving continuous improvement; ability to identify emerging trends in screening technologies.
- Proactive problem-solving, operational excellence, and strong balance of technical and strategic capabilities.
- Travel: Limited travel between PTC facilities in New Jersey
- Physical requirements: Lab and Office based position
Skills
- Advanced planning and leadership for high-throughput screening campaigns
- Cross-functional collaboration and communication
- Automation and robotics familiarity in screening workflows
- Data analysis and reporting
- Inventory management and quality control
Education
- Bachelor’s degree in chemistry, biology, biochemistry, or related field (required)
- Master’s degree or Ph.D (preferred)
Additional Requirements
- Regulatory and safety compliance knowledge