Manager IT Infrastructure, Network & Security Operations

Manager IT Infrastructure, Network & Security Operations

Company Name: Sangamo Therapeutics, Inc.

Sangamo Therapeutics is a genomic medicine company focused on treating debilitating neurological diseases, by using our wholly owned, highly versatile zinc finger epigenetic regulation technology and capsid delivery engine. We are passionate about designing and developing genomic medicines to transform the lives of patients suffering from severe diseases with our deep scientific expertise and proprietary zinc finger genome engineering technology. At Sangamo, we are dedicated to building a robust, sustainable genomic medicine pipeline that addresses life-limiting conditions by replacing today’s symptom-focused treatments with tomorrow’s genomic cures. Our top priority is to meet the needs of patients with commitment and compassion. Along with our commitment to science and to our patients, we also endeavor to create an inclusive environment that promotes and values diversity. Sangamo is a company where individuals can flourish, grow and develop their expertise.

We are seeking top talent to join our mission. Let’s build a better future together.

Job Summary

We are seeking a hands-on and strategic IT Manager to lead our infrastructure, network, and security operations. This role will be responsible for the stability, security, and performance of both on-premises and cloud-based systems. The ideal candidate will be experienced in system and network architecture, cybersecurity practices, and automation, with a strong understanding of compliance and governance frameworks such as SOX and NIST. This is an onsite role with the flexibility to work remotely according to business and department needs. We are only considering candidates local to the San Francisco Bay Area.

Essential Functions

• Lead daily IT operations including server, network, cloud (Azure & AWS), and endpoint environments
• Manage infrastructure security, including incident response, patch management, vulnerability remediation, and endpoint protection
• Monitor system performance and ensure high availability, scalability, and disaster recovery capabilities
• Oversee firewall, VPN, and network segmentation architecture and operations
• Maintain and optimize AWS cloud resources for cost efficiency and security
• Administer Okta SSO platform for identity and access management
• Manage and oversee external Managed Service Providers (MSPs) to ensure service quality and accountability
• Collaborate with internal teams and vendors to deliver secure, scalable, and stable IT operations
• Refine and maintain IT operational processes, SOPs, runbooks, and documentation to ensure clarity, consistency, and audit-readiness
• Ensure compliance with SOX, GxP, GMP, and implement controls aligned with the NIST cybersecurity framework
• Manage Microsoft 365 environment including Exchange Online, Azure AD, and Microsoft Defender
• Support IT audits, risk assessments, and quarterly security reporting
• Drive automation efforts using scripting tools (e.g., PowerShell, Python)

Education, Experience And Skills Requirements

• Bachelor’s degree in Computer Science, Information Technology, or equivalent work experience
• 7+ years of experience in IT infrastructure, networking, and/or security operations
• 2+ years in a management or team lead capacity
• Experience managing external MSPs and third-party service providers
• Proficient in:
• Windows Server, Active Directory, DNS/DHCP
• Endpoint management tools (Endpoint Central, Action1, Intune)
• Cloud infrastructure (Azure, AWS), including cost and performance optimization
• Firewall and VPN technologies (e.g., Palo Alto, Cisco)
• Identity and access management tools, especially Okta SSO
• Strong experience developing and refining IT processes and standard operating procedures (SOPs)
• Deep understanding of patch management, threat remediation, and log analysis
• Familiarity with security and compliance frameworks, including NIST CSF, ISO 27001, and SOX
• Experience implementing or maintaining controls aligned to the NIST framework

Preferred Skills & Qualifications

• Certifications: CISSP, CISM, CompTIA Security+, AWS Certified Solutions Architect, Microsoft Certified: Azure Administrator, Cisco CCNP
• Familiarity with:
• Microsoft Purview and compliance tools
• Email security tools (e.g., Abnormal Security or similar tools)
• Cybersecurity awareness platforms (e.g., KnowBe4)
• ITSM platforms (e.g., FreshService, ServiceNow)
• Generative AI tools and platforms (e.g., Microsoft Copilot, Zoom AI Companion, ChatGPT)

We believe in the value of diverse perspectives and backgrounds, and we welcome candidates who are eager to learn and contribute to our mission. We encourage you to apply even if you don’t meet all the qualifications. Share what differentiates you from other candidates.

Sangamo is an equal opportunity employer

Sangamo is committed to fostering belonging for all employees and embraces diversity, equity, and inclusion in recruiting and hiring. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual’s race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws.

Pay Range

The anticipated salary range is for candidates who will work in our San Francisco Bay Area work locations. The final salary offered to a successful candidate will be dependent on several factors that may include, but are not limited to, the type and length of experience with the job, type and length of experience within the industry, education, etc. This salary range may not apply to remote positions that work in other states.

Note to External Recruiters

We do not accept unsolicited resumes from any source other than from the candidates themselves. If you wish to be considered for the presentation of candidates, please email recruiting@sangamo.com. We will reach out to you directly if there is a business need for your services.